Evidence map›Paper›PMID 41462366›Full record

ArticleAntimicrobial resistance and infection control2025

Local translation of national guidance on discontinuing COVID-19 isolation into hospital policies results in considerable differences.

Cynthia P Haanappel, Juliëtte A Severin, Karin Ellen Veldkamp, Jean-Luc Murk, Anne J G Mutsaers van Oudheusden, Emile Schippers, Matthew B B McCall, Carla van Tienen, Jeroen J A van Kampen, Marion P G Koopmans and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cynthia P HaanappelDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Juliëtte A SeverinDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Karin Ellen VeldkampCenter for Infectious Diseases, Subdepartment of Medical Microbiology & Infection Control, Leiden University, Leiden University Medical Center, Leiden, The Netherlands.
Jean-Luc MurkMicrovida, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
Anne J G Mutsaers van OudheusdenDepartment of Infection Prevention and Control, Elisabeth TweeSteden Hospital, Tilburg, The Netherlands.
Emile SchippersDepartment of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
Matthew B B McCallDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Carla van TienenDepartment of Medical Microbiology, Maasstad Hospital, Rotterdam, The Netherlands.
Jeroen J A van KampenDepartment of Viroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Marion P G KoopmansDepartment of Viroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Rob KlontDepartment of Medical Microbiology, Medisch Spectrum Twente, Enschede, The Netherlands.
Bastiaan E KellerhuisJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Kevin JenniskensJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Johannes B ReitsmaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Margreet C Vos *Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Anne F Voor In 't Holt *Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands. a.voorintholt@erasmusmc.nl.
SCIP-COVID-19 project consortium

Funding

The Netherlands Organisation for Health Research and Development (ZonMw) 10430102110003
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic underscored the vital role of infection prevention and control (IPC) policies in hospitals to protect patients and healthcare workers. National guidance documents have traditionally provided a framework for local IPC policy development. This study aimed to examine the translation of the Dutch national COVID-19 IPC guidance documents into local Dutch hospital policies, specifically focusing on discontinuing isolation measures for COVID-19 patients.

methodsThis multicentre retrospective study investigated the IPC policies of seven Dutch hospitals, of which three academic hospitals and four non-academic hospitals. IPC practitioners collected data from hospitals' (archived) IPC policy guidelines implemented between March 2020 and December 2021. A composite index based on the criteria for discontinuation of isolation measures for COVID-19 patients was created to capture variation in policy translation within and across hospitals over time, relative to the national guidance document. Using this index, a descriptive analysis was performed to assess the extent to which hospitals adopted the national guidance for discontinuing isolation measures for specific patient groups.

resultsThe national COVID-19 IPC guidance document for discontinuing isolation measures established targeted criteria for six patient groups, and included criteria based upon days since symptom onset, symptoms, symptom-free period, and RT-PCR results. Hospitals distinguished 16 patient groups. While the national guidance was updated regularly, the criteria for discontinuing isolation measures changed once; the frequency of local hospital updates ranged from four to 12 times. Policy variation was observed both within and across local hospital policies over time. Local hospital policies tended to be less strict for patients on ventilation and/or with a tracheostomy (78% of the time), while for other patient groups, they were more often stricter.

conclusionsCompared to the national guidance, local hospital guidelines showed more variety in the number of patient groups described as well as more policy changes throughout the first two years of the pandemic. Furthermore, variation was observed within and between hospitals over time. These variations show the complexity of striving for a uniform and unambiguous policy on a national level, and indicate the need for awareness of the presence of variation in settings regarding patient groups and infrastructure.

Indexed as

COVID-19HospitalsInfection ControlPatient IsolationHealth PolicyHumansNetherlandsRetrospective StudiesSARS-CoV-2COVID-19Health policyHospitalInfection controlIsolation measuresPandemic preparednessSARS-CoV-2

Identifiers

PMID41462366
PMCPMC12751809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.