ArticleNutrition journal2025
Intake of dietary carotenoids and flavonoids at midlife and risk of physical frailty at late life: the Singapore Chinese Health Study.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAlthough Western studies have suggested that dietary carotenoids and flavonoids may reduce the risk of ageing-related physical frailty, evidence from prospective Asian studies is limited. We examined the association between midlife intake of these phytochemicals and risk of physical frailty among Chinese adults in Singapore.
methodsThis study included 10,738 participants from the population-based prospective cohort of the Singapore Chinese Health Study. Dietary information was collected using a validated 165-item semi-quantitative food frequency questionnaire at recruitment from 1993 to 1998 (mean age 51 years, range 45-60 years). During follow-up 3 interviews from 2014 to 2017, physical frailty was assessed using a modified version of the Cardiovascular Health Study phenotype (mean age 72 years, range 63-84 years). Multivariable logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between nutrient intake and physical frailty.
resultsAmong the 10,738 participants in the current study, 58.3% were female. Over a mean (SD) follow-up period of 20 (1.9) years, 1,220 participants (11.4%) were identified as being physically frail. Higher baseline consumption of carotenoids and flavonoids were associated with lower odds of physical frailty at follow-up 3. Compared to those in the lowest quintiles, the ORs (95% CIs) for the association with physical frailty for those in the highest quintiles were 0.69 (0.55-0.85) for total carotenoids (p-trend = 0.001) and 0.80 (0.64-0.99) for total flavonoids (p-trend = 0.019). Specifically, total carotenoid intake showed significant inverse association with weakness defined by weak handgrip; the OR (95% CI) comparing extreme quintiles was 0.60 (0.49-0.72) (p-trend = 0.001). Conversely, flavonoid intake was inversely associated with slow timed-up-and-go test, with an OR (95% CI) of 0.83 (0.67-1.03) for the extreme quintiles (p-trend = 0.021). For individual nutrients, significant inverse associations between consumption and odds of physical frailty were found for alpha-carotene, beta-carotene and lutein among carotenoids, and for flavan-3-ols, flavonese and flavonols among flavonoids.
conclusionHigher dietary intake of carotenoids and flavonoids during midlife may be beneficial in reducing physical frailty in later life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.