Observational studyBMC nephrology2025
Plasma monocyte chemoattractant protein-1 and the risk of kidney and cardiovascular outcomes in people with chronic kidney disease: results from the BRIGHTEN study.
Observational study in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
backgroundMonocyte chemoattractant protein-1 (MCP-1) has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its clinical significance in CKD remains unclear. This study investigated the association between plasma MCP-1 levels and kidney and cardiovascular outcomes in patients with CKD.
methodsThis multicenter, prospective, observational analysis used data from the BRIGHTEN study. Participants with anemia and CKD (eGFR < 60 mL/min/1.73 m
resultsThis study included 1,447 participants with advanced CKD (median eGFR 17.9 mL/min/1.73 m²). The group with the lowest MCP-1 level (< 324.5 pg/mL) had the highest baseline eGFR. In the univariable analyses, higher MCP-1 levels were associated with an increased risk of kidney and cardiovascular outcomes (log-rank p < 0.01 and p = 0.03, respectively), although these associations were not significant after multivariable adjustment. Analysis of the annual eGFR decline using a multivariable linear mixed-effects model revealed that higher MCP-1 levels were associated with an additional eGFR decline of approximately 1.0 mL/min/1.73 m
conclusionsIn patients with CKD, higher plasma MCP-1 levels are associated with a more rapid decline in kidney function but not with the composite outcome of kidney failure. MCP-1 was not associated with cardiovascular outcomes or mortality in this population cohort.
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