SynthesisBMC cancer2025
Efficacy of behaviour change interventions to influence human papillomavirus (HPV) vaccine uptake: a systematic review and behaviour change techniques analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehaviour change interventions that increase human papillomavirus (HPV) vaccine uptake in school children have been identified, but not which behaviour change techniques (BCTs) make them effective, or whether interventions are best targeted towards adolescents or their parent/carer(s). We aimed to assess the efficacy of behaviour change interventions to increase HPV vaccination compared to usual care according to BCTs implemented, and to identify whether parent/carer(s), adolescents or both are the optimal intervention target population.
methodsWe searched Central, Embase, Medline and Eric databases from 1st September 2008 to 17th July 2023 for randomised controlled trials (RCTs) reporting on HPV vaccine uptake following behaviour change interventions. We coded BCTs in interventions using the BCT taxonomy (v1). Random-effects meta-analyses and subgroup analyses were performed with data from studies that provided count data on HPV vaccine uptake by BCTs implemented and intervention target population.
resultsOne thousand three hundred sixty-three unique records were identified, of which eight were eligible for inclusion. Implementing any behaviour change intervention was associated with a borderline significant increase in HPV vaccine uptake (OR 1.2 95% CI 1.0 to 1.4), interventions that implemented 'Instruction on how to perform the behaviour' (BCT 4.1) and 'Information about health consequences' (BCT 5.1) were not associated with increased HPV vaccine uptake (OR 1.7 95% CI 0.8 to 3.5), but analysis of two interventions implementing 'Adding objects to the environment' (BCT 12.5) in addition showed that this combination may be associated with significantly greater HPV vaccination (OR 13.6 95% CI 3.9 to 46.5). We found that interventions targeting parent/carer(s)-only were associated with a small significant increase in HPV vaccine uptake (OR 1.3 95% CI 1.1 to 1.5), but adolescent-only or parent/carer(s) and adolescent targeted interventions were not.
conclusionsTo our knowledge this is the first systematic review and meta-analysis to quantify the efficacy of behaviour change interventions to increase HPV vaccine uptake according to BCTs implemented. We have demonstrated that implementing any behaviour change intervention marginally increases HPV vaccine uptake, and have identified a combination of BCTs that may be associated with significantly increased HPV vaccine uptake. Our work provides compelling evidence that public health interventions must be specific and evidence-based and calls for the implementation of changes to usual care in school-based vaccination programmes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.