Observational studyBMC cancer2025
Diagnostic value of peripheral blood inflammatory indices for breast cancer grade and immunohistochemical markers: a retrospective observational study.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Association Between Neutrophil-to-Lymphocyte Ratio and Histological Tumor Differentiation in Solid Malignancies: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- The prognostic value of lymphocyte-albumin-neutrophil ratio variability in patients with breast cancer undergoing radiotherapy.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBreast cancer remains a leading global health burden with rising incidence, particularly in low- and middle-income countries. Emerging evidence suggests that systemic inflammatory indices may correlate with malignancies' prognostic features. This study aimed to evaluate the diagnostic value of six peripheral blood inflammatory indices, including systemic immune-inflammation index (SII), lymphocytes-albumin to neutrophils ratio (LANR), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), hemoglobin-to-red cell distribution width ratio (HRR), and glucose-to-lymphocyte ratio (GLR), in predicting breast tumor grade and immunohistochemical (IHC) markers expression.
methodsThis retrospective observational study involved 114 patients with breast cancer, admitted to Rasoul-Akram Hospital from September 2020 to 2024, undergoing elective tumor resection. Tumor grade and ER, PR, and HER2 expression were determined via biopsy. Ordinal logistic regression was applied to determine tumor grade and IHC marker expression predictors. ROC curve analyses were used to assess the diagnostic performance of significant indices.
resultsAmong all indices, NLR showed a statistically significant association with tumor grade (p = 0.027), with higher NLR correlating with poorer differentiation. Additionally, ordinal regression analyses show that NLR and LANR were significantly associated with HER2 expression status. ROC analysis of NLR revealed moderate diagnostic value for tumor grade (AUC = 0.652, cutoff = 2.15, sensitivity = 59.3%, specificity = 69.0%). Other indices did not demonstrate significant predictive capacity for grade or IHC markers expression.
conclusionNLR, a cost-effective and widely accessible marker, showed moderate diagnostic value for predicting tumor grade and HER2 status in breast cancer. Incorporating NLR into preoperative evaluations may aid early risk stratification and guide individualized treatment planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.