Observational studyBMC infectious diseases2025
Mapping the distribution of yaws and Haemophilus ducreyi in the western north region of Ghana.
Observational study in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Haemophilus ducreyi Bacteria Causing Cutaneous Ulcer Outbreak in Children, Sierra Leone, December 2025.Emerging infectious diseases · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundTreponema pallidum subspecies pertenue and Haemophilus ducreyi cause skin ulcers in impoverished communities. Historical serologic records from Ghana focus on T. pallidum, omitting potential H. ducreyi cases. The objective of this study was to investigate, for the first time, the presence and distribution of T. p .subsp. pertenue and/or H. ducreyi in skin lesions in two previously unstudied areas in Western North Region of Ghana.
methodsWe conducted observational cross-sectional surveys and screened skin lesions in the Aowin municipality and Suaman district in Western North Region, Ghana. Suspected yaws cases were tested for 1) treponemal and non-treponemal antibodies using a finger-prick blood test and 2) Treponema pallidum and H. ducreyi DNA in lesion swabs using polymerase chain reaction (PCR). GPS coordinates were recorded for all tests administered near patients' schools or residences.
resultsOf the 11,917 individuals examined, 1,699 patients with suspected yaws consented to testing. In the Aowin municipality, the seroprevalence of current treponemal infections was 10.8%, while the prevalence of yaws and H. ducreyi, confirmed by PCR, was 2.3% and 4.3%, respectively. High RPR titers correlated with active yaws infection. However, T. pallidum DNA was confirmed in lesions with low RPR titers (≤1:4). Communities with high seropositivity rates were more likely to have PCR-confirmed yaws cases. No evidence of resistance to azithromycin was observed in T. p. subsp. pertenue isolates. Dual infections with H. ducreyi were uncommon. No treponemal-positive cases were identified in the Suaman district.
conclusionsSerological surveillance without molecular testing may undermine efforts to interrupt yaws transmission. More comprehensive community surveillance detecting yaws and H. ducreyi infections is critical in developing strategies to achieve the WHOs yaws eradication goal.
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