Evidence map›Paper›PMID 41462086›Full record

ArticleBMC microbiology2025

Innovative application of mefloquine and Methacycline in combating Tet(X3/X4)-positive Escherichia coli infections.

Qianyu Zhou, Jinjing Xue, Jun Li, Zhiying Liu, Yinuo Zou, Rui Dai, Kuan Gu, Yonglin Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qianyu ZhouKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Jinjing XueKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, School of Life Sciences, Ningxia University, Yinchuan, China.
Jun LiKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, School of Life Sciences, Ningxia University, Yinchuan, China.
Zhiying LiuKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Yinuo ZouKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Rui DaiKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Kuan GuSchool of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. gukuannn@163.com.
Yonglin ZhouKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. zhouyonglin333@nxu.edu.cn.

Funding

Ningxia Hui Autonomous Region Key R&D Program 2021BEF02021the National Natural Science Foundation of China 32202856
6 · The paper itself

Abstract

The advent and global spread of plasmid-carried resistance genes, including the tigecycline resistance gene tet(X3/X4) and the colistin resistance gene mcr-1, present a substantial threat to public health that requires immediate resolution. This study successfully screened and identified commercial anti-parasitic drugs that efficiently inhibit Tet(X4) enzyme activity (IC

Indexed as

Anti-Bacterial AgentsEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsMefloquineAnimalsDisease Models, AnimalDrug SynergismFemaleMiceMicrobial Sensitivity TestsMolecular Dynamics SimulationAnti-Bacterial AgentsEscherichia coli ProteinsMefloquineEscherichia coliMefloquineMethacyclineSynergistic effectTet(X4)

Identifiers

PMID41462086
PMCPMC12751748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.