Evidence map›Paper›PMID 41462066›Full record

ArticleThe journal of headache and pain2025

Impact of caffeine consumption on headache severity, sleep quality, and psychiatric symptoms in patients with idiopathic intracranial hypertension: a cross-sectional study.

Mohamed Abdelghaffar, Mona Hussein, Rehab Magdy, Anas Elgenidi, Ahmed Dahshan, Nourhan Abdelmohsen Taha, Nahla Merghany, Ahmed Essmat, Amr Hassan, Ramez Reda Moustafa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohamed AbdelghaffarDepartment of Neurology, Fayoum University, Fayoum, Egypt.
Mona HusseinDepartment of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Rehab MagdyDepartment of Neurology, Cairo University, Cairo, Egypt.
Anas ElgenidiDepartment of Neurology, Mayo Clinic, Florida, USA.
Ahmed DahshanDepartment of Neurology, Cairo University, Cairo, Egypt.
Nourhan Abdelmohsen TahaDepartment of Neurology, Ain Shams University, Cairo, Egypt.
Nahla MerghanyDepartment of Neurology, Cairo University, Cairo, Egypt.
Ahmed EssmatDepartment of Neurology, Al Azhar University, Cairo, Egypt.
Amr HassanDepartment of Neurology, Cairo University, Cairo, Egypt.
Ramez Reda MoustafaDepartment of Neurology, Ain Shams University, Cairo, Egypt.
May M FayezDepartment of Neurology, El Mounira Hospital, Cairo, Egypt.
Anter Mothenna Abdullah NasserDepartment of Neurology, Thamar University, Sana'a Street, Dhamar, 009676, Yemen. aljilanyanter@gmail.com.
Osama YacoubDepartment of Neurology, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between caffeine consumption and idiopathic intracranial hypertension (IIH) remains an area of clinical interest, but with limited research. This work aimed to clarify the impact of caffeine consumption on headache severity, quality of life, psychiatric symptoms, and sleep quality in patients with IIH.

methodsThis cross-sectional study included 179 patients diagnosed as having IIH. At the baseline visit, the patients underwent a detailed clinical assessment. They were subsequently asked to complete a set of self-administered questionnaires after one month: the Caffeine Food Frequency questionnaire (C-FFQ), Headache Impact Test-6 (HIT-6), Depression Anxiety Stress Scale-12 (DASS-12), Insomnia Severity Index (ISI), and the Short-Form Health Survey (SF-12). Patients were categorized as heavy caffeine consumers (≥ 400 mg/day), light consumers (< 400 mg/day), or non-consumers.

resultsHeavy caffeine consumers showed significantly higher rates of severe papilledema, elevated CSF pressure, and greater daily dose of acetazolamide compared to light and non-consumers (P < 0.001). Headache burden was significantly greater among heavy consumers compared to light and non-consumers, with higher median monthly headache days (MHDs) [20 vs. 15 vs. 10], visual analogue scale (VAS) pain scores [9 vs. 7 vs. 7], and HIT-6 scores [66 vs. 63 vs. 57] (all P < 0.01). Moreover, heavy consumers reported significantly lower quality of life on SF-12 physical and mental domains, and higher DASS-12 and ISI scores compared to light and non-consumers (P < 0.001).

conclusionIn IIH patients, heavy caffeine consumption was associated with worse headache burden, impaired quality of life, and increased psychiatric and sleep disturbances.

Indexed as

CaffeineCentral Nervous System StimulantsHeadachePseudotumor CerebriSleep QualityAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesCaffeineCentral Nervous System StimulantsCaffeineIdiopathic intracranial hypertensionInsomniaPsychiatric symptomsQuality of life

Identifiers

PMID41462066
PMCPMC12859903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.