Trial reportScientific reports2025
Dietary management and aerobic exercise counselling on blood pressure control in subjects with prehypertension and drug-naïve stage 1 hypertension: a randomized clinical trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05274971 (Dietary Management and Aerobic Exercise on 24-hour Ambulatory Blood Pressure in Subjects with Prehypertension and Drug-naïve Stage 1 Hypertension), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Management and Aerobic Exercise on 24-hour Ambulatory Blood Pressure in Subjects with Prehypertension and Drug-naïve Stage 1 Hypertension: Randomized, Single-blinded Clinical Trial
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Non-pharmacological interventions for blood pressure management in hypertensive patients: selection of exercise regimens-a systematic review and network meta-analysis.Frontiers in endocrinology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While lifestyle modification is recommended as first-line treatment for lowering blood pressure (BP) in individuals with prehypertension and drug-naïve stage 1 hypertension, there is a paucity of randomized controlled data on such subjects. This multicenter, open-label, randomized clinical trial enrolled 70 participants (N = 35 per group) with prehypertension and drug-naïve stage 1 hypertension, defined as a systolic BP (SBP) of 130-159 mmHg and/or a diastolic BP (DBP) of 85-99 mmHg. The diet & exercise (D&E) group received counseling and monitoring on diet (DASH; dietary approaches to stop hypertension) and regular physical exercise for 12 weeks. The primary outcome was the change in systolic and diastolic BP after 12 weeks. Secondary outcomes included the 24-hour BP and its components and inflammatory markers. Compared with the control group, office SBP and DBP were reduced in the D&E group by 15.1 (-8.73 vs. 6.38 mmHg, p = 0.003) and 6.68 (-4.57 vs. 2.11 mmHg, p = 0.003) mmHg, respectively. The 24-hour ambulatory SBP did not change significantly in either group after 12 weeks (-0.72 vs. 1.92 mmHg, p = 0.667). In subgroup analysis, female, older-age participants and participants with higher baseline BP showed higher reductions in office SBP. Positive effects on office BP were noted by dietary and exercise education, especially in female and older-age participants.Trial registration: 15/05/2022, NCT05274971.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.