Evidence map›Paper›PMID 41462011›Full record

ArticleCell death & disease2025

CCL20 secreted by KRT15

Siwei Zhang, Huan Liu, Xiaoxing Li, Yourong Jiang, Lu Tang, Tianyang Liu, Rui Li, Zengchen Liu, Minghui Wei, Jingchun Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siwei ZhangNational Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.ORCID http://orcid.org/0000-0003-2615-5943
Huan LiuNational Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.
Xiaoxing LiDepartment of Pathology, The Third People's Hospital of Shenzhen, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.
Yourong JiangDepartment of Stomatology, Jining Medical University, Jining, Shandong, 272067, China.
Lu TangDepartment of Stomatology, Hubei Polytechnic Institute, Xiaogan, Hubei, 432000, China.
Tianyang LiuNational Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.
Rui LiDepartment of neurosurgery, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.
Zengchen LiuDepartment of neurosurgery, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China.
Minghui WeiDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Jingchun SunDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Zhuledesi HahanDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Heng MaDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China. 07301020033@fudan.edu.cn.
Lanlan WeiNational Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, 518000, China. weilanlan@mail.sustech.edu.cn.ORCID http://orcid.org/0000-0001-9472-1965

Funding

Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2023A1515220104National Natural Science Foundation of China (National Science Foundation of China) 82473326Shenzhen Science and Technology Innovation Commission JCYJ20240813101802004Shenzhen Science and Technology Innovation Commission JCYJ20240813101805007
6 · The paper itself

Abstract

Tertiary lymphoid structures (TLS) are associated with an improved response to Immune checkpoint therapy (ICT) in head and neck squamous cell carcinoma (HNSCC). Human papillomavirus (HPV) infection constitutes a high-risk factor for HNSCC carcinogenesis. However, its role in TLS formation has yet to be elucidated. Herein, immunohistochemical (IHC) analysis from 59 HNSCC patients revealed a higher prevalence of mature TLS in HPV-positive (HPV

Indexed as

Chemokine CCL20Head and Neck NeoplasmsImmune Checkpoint InhibitorsPapillomavirus InfectionsProgrammed Cell Death 1 ReceptorSquamous Cell Carcinoma of Head and NeckTertiary Lymphoid StructuresAnimalsCell Line, TumorFemaleHumansMaleMiceCCL20 protein, humanChemokine CCL20Immune Checkpoint InhibitorsProgrammed Cell Death 1 Receptor

Identifiers

PMID41462011
PMCPMC12858956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.