Evidence map›Paper›PMID 41462000›Full record

ArticleMolecular imaging and biology2026

A Bioimaging Study of

Hui K Gan, Sagun Parakh, Sze Ting Lee, Graeme J O'Keefe, Jodie Palmer, Jared Mathai, Vivian Smith, Christian W Wichmann, Alexander F McDonald, Nancy Guo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui K Gan *Medical Oncology, Austin Hospital, Heidelberg, Melbourne, Australia. Hui.Gan@austin.org.au.
Sagun Parakh *Medical Oncology, Austin Hospital, Heidelberg, Melbourne, Australia.ORCID http://orcid.org/0000-0003-3891-2489
Sze Ting LeeTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Graeme J O'KeefeDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Jodie PalmerTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Jared MathaiMedical Oncology, Austin Hospital, Heidelberg, Melbourne, Australia.
Vivian SmithMedical Oncology, Austin Hospital, Heidelberg, Melbourne, Australia.
Christian W WichmannTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Alexander F McDonaldTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Nancy GuoTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Fiona E ScottTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.
Andrew M ScottTumor Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleBintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the human transforming growth factor β receptor II (TGF-βRII or TGF-β "trap") and human immunoglobulin 1 antibody which blocks programmed cell death ligand 1 (PD-L1). This trial aimed to investigate the biodistribution of

methodsFive lung cancer patients were recruited with PD-L1 staining more than 1% of tumor cells. Patients underwent

results

conclusions

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPositron-Emission TomographyRadioisotopesRecombinant Fusion ProteinsZirconiumAgedFemaleHumansMaleMiddle AgedNeoplasm MetastasisTissue DistributionRadioisotopesRecombinant Fusion ProteinsZirconiumZirconium-89Human transforming growth factor β receptor IINSCLCPDL-1PET scanTheranostic

Identifiers

PMID41462000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.