Evidence map›Paper›PMID 41461927›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

Urinary metabolome dynamics in

Annelaure Damont, Anaïs Legrand, Kathleen Rousseau, Laurent Bellanger, Séverine Boiry, Frédéric Gibiat, Jean-Jacques Leguay, Christophe Junot, François Fenaille, Eric Ezan

Abstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Annelaure Damont *Paris-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France. annelaure.damont@cea.fr.
Anaïs Legrand *Paris-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France.
Kathleen RousseauParis-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France.
Laurent BellangerParis-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), F-30200, Bagnols-sur-Cèze, France.
Séverine BoiryAix Marseille University, CEA, CNRS, BIAM, F-13115, Saint Paul-Lez-Durance, France.
Frédéric GibiatAix Marseille University, CEA, CNRS, BIAM, F-13115, Saint Paul-Lez-Durance, France.
Jean-Jacques LeguayParis-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France.
Christophe JunotParis-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France.
François Fenaille *Paris-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France. francois.fenaille@cea.fr.
Eric Ezan *Paris-Saclay University, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), MetaboHUB, F-91191, Gif sur Yvette, France.

Funding

Agence Nationale de la Recherche ANR-11-INBS-0010Agence Nationale de la Recherche ANR-21-ESRE-0035
6 · The paper itself

Abstract

introductionAnalysis of specific pathways of metabolic flux is usually achieved by administering stable isotope-labeled precursors and measuring their incorporation into selected metabolites by high-resolution mass spectrometry coupled to liquid chromatography (LC-HRMS).

objectivesIn this study, we undertook a novel approach aiming at covering the whole metabolome dynamics by providing mice with a diet fully enriched in carbon-13 (

methodsThree animals were fed for six weeks with small pellets composed of a mixture of

resultsComparative LC-HRMS analysis of the

conclusionThis study demonstrates that mice tolerate a diet entirely labeled with carbon-13 (> 97 atom %

Indexed as

Carbon IsotopesMetabolomeMetabolomicsUrineAnimalsChromatography, LiquidIsotope LabelingMaleMass SpectrometryMiceMice, Inbred C57BLCarbon-13Carbon Isotopes13C-metabolomicsIn vivoIsotope tracingMammal labelingMass spectrometry

Identifiers

PMID41461927
PMCPMC12748121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.