Evidence map›Paper›PMID 41461903›Full record

ArticleEndocrine2025

Estimated glucose disposal rate (eGDR) and prehypertension in Non-Diabetic Japanese adults: A secondary analysis of the NAGALA Cross-Sectional study.

Dexi Wu, Qinqin Wang, Feng Wen, Yasha Chen, Hui Chen, Yue Wu, Zhiqing He, Chun Liang

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Dexi WuDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Qinqin WangDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Feng WenDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yasha ChenDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Hui ChenDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yue WuDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Zhiqing HeDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. dragonhzq@yeah.net.
Chun LiangDepartment of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. chunliangliang@126.com.

Funding

Clinical Collaboration Program of Traditional Chinese and Western Medicine for Major and Intractable Diseases ZDYN-2024-A-154National Key R&D Program of China 2022YFC3501701NSFC grants 82120108004Shanghai foundation for supporting the military and families E3F2A20102
6 · The paper itself

Abstract

purposeThe association between estimated glucose disposal rate (eGDR) and prehypertension (pre-HTN) in non-diabetic Japanese adults was investigated in our study.

methodsData from 15,464 participants aged 18–79 years in the NAGALA-based study (2004–2015) were further analyzed. A total of 14,170 non-diabetic individuals were included to explore the association between eGDR—calculated using two established formulas, one based on waist circumference (WC) and the other on body mass index (BMI)—and pre-HTN. Multivariable logistic regression adjusted for serum biomarkers and clinical characteristics was used to evaluate the relationship. Both stratified analysis and Bayesian network (BN) models have been employed to further substantiate this relationship.

results30.1% of pre-HTN were shown in the enrolled patients (4,266/14,170). After adjusting for confounders, lower eGDR levels were significantly associated with higher pre-HTN risk. The adjusted odds ratio for the first tertile of eGDR.WC and eGDR.BMI, compared to the highest tertile, were 3.36 (95%CI: 2.99–3.77) and 3.39 (95%CI: 3.04–3.78) respectively. An increase of 1-unit in eGDR was found to link with a 52% reduction in the prevalence of pre-HTN for eGDR.WC (adjusted OR = 0.48, 95%CI: 0.45–0.51) and a 60% reduction for eGDR.BMI (adjusted OR = 0.40, 95%CI: 0.38–0.43). Stratified analysis confirmed a negative correlation between eGDR and pre-HTN across subgroups, which was also corroborated in BN models.

conclusionsIn non-diabetic Japanese adults, lower eGDR levels were significantly associated with higher pre-HTN prevalence, suggesting eGDR as a potential indicator for hypertension prevention and deserving more clinical research’s validation.

Indexed as

Blood GlucosePrehypertensionAdolescentAdultAgedBody Mass IndexCross-Sectional StudiesEast Asian PeopleFemaleHumansJapanMaleMiddle AgedWaist CircumferenceYoung AdultBlood GlucoseEstimated glucose disposal rate (eGDR)Insulin resistanceNon-diabetesPrehypertension

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PMID41461903

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