ArticleNature cardiovascular research2026
A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects.
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Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Review
- Expression of Netrin-1 in the developing mouse heart.Gene expression patterns : GEP · 2025Article
- TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.Circulation · 2025Article
- Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues.Cell reports methods · 2025Article
Corrections and comments
- Update of
Authors and funding
21 authors.
Irfan S KathiriyaDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA. irfan.kathiriya@ucsf.edu.ORCID http://orcid.org/0000-0003-1207-1490
Martin H DominguezGladstone Institutes, San Francisco, CA, USA.
Kavitha S RaoDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA.
Jonathon M Muncie-VasicGladstone Institutes, San Francisco, CA, USA.
W Patrick DevineGladstone Institutes, San Francisco, CA, USA.
Kevin M HuDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5513-7854
Swetansu K HotaGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3105-9729
Bayardo I GarayDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1458-6095
Diego QuinteroGladstone Institutes, San Francisco, CA, USA.
Piyush GoyalDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA.
Megan N MatthewsDepartment of Anesthesia and Perioperative Care, University of California, San Francsisco, San Francisco, CA, USA.
Reuben ThomasGladstone Institutes, San Francisco, CA, USA.
Tatyana SukonnikGladstone Institutes, San Francisco, CA, USA.
Dario Miguel-PerezGladstone Institutes, San Francisco, CA, USA.
Sarah WinchesterGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2924-4757
Emily F BrowerGladstone Institutes, San Francisco, CA, USA.
André ForjazDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0002-5115-2293
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7371-2960
Denis WirtzDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Ashley L KiemenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6281-2616
Benoit G BruneauGladstone Institutes, San Francisco, CA, USA. benoit.bruneau@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-0804-7597
Funding
Tech Core 2U54CA268083 · NCI · JOHNS HOPKINS UNIVERSITY · PI Pei-Hsun wu · 2022 to 2026
$10.2MEarly Cardiac ProgenitorsR01HL114948 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Benoit Gaetan Bruneau · 2013 to 2026
$7.5MThe Epigenetic Landscape of Heart DevelopmentUM1HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2015 to 2019
$4.7MGene regulatory networks for heart developmentR01HL155906 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN · 2021 to 2024
$2.4MEXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1MEngineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptorsR01CA300052 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2025 to 2026
$1.3MThree-dimensional maps of senescence in the human pancreasUG3CA275681 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, PEI-HSUN · 2022 to 2023
$1.1MPatterning Mechanisms for Ventricular Septation and Congenital Heart DiseaseR56HL166894 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATHIRIYA, IRFAN S · 2024 to 2024
$605kUncovering the Mechanisms that Enable Cardiac Progenitors to Build the Linear Heart TubeK99HL177318 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Jonathon Michael Muncie-Vasic · 2025 to 2026
$270kDefining the Cellular Morphogenic Behaviors that Shape the Developing HeartF32HL162450 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI MUNCIE-VASIC, JONATHON MICHAEL · 2022 to 2023
$137kNCI NIH HHS R01 CA300052NCI NIH HHS U54 CA268083NCI NIH HHS UG3 CA275681NCRR NIH HHS C06 RR018928NHLBI NIH HHS F32 HL162450NHLBI NIH HHS K99 HL177318NHLBI NIH HHS R01 HL114948NHLBI NIH HHS R01 HL155906NHLBI NIH HHS R56 HL166894NHLBI NIH HHS UM1 HL098179U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R56HL166894-01A1U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL114948U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL155906U.S. Department of Health & Human Services | National Institutes of Health (NIH) U54CA268083U.S. Department of Health & Human Services | National Institutes of Health (NIH) UG3CA275681U.S. Department of Health & Human Services | National Institutes of Health (NIH) UM1HL098179
Abstract
Failure of septation of the interventricular septum (IVS) is the most common congenital heart defect, but mechanisms for patterning the IVS are largely unknown. Here we show that a Tbx5
Indexed as
Body PatterningHeart Defects, CongenitalHeart Septal Defects, VentricularT-Box Domain ProteinsAnimalsCell LineageGene Expression Regulation, DevelopmentalIntercellular Signaling Peptides and ProteinsMEF2 Transcription FactorsMiceMice, TransgenicNerve Tissue ProteinsIntercellular Signaling Peptides and ProteinsMEF2 Transcription FactorsNerve Tissue ProteinsT-Box Domain ProteinsT-box transcription factor 5
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.