Evidence map›Paper›PMID 41461893›Full record

ArticleScientific reports2025

M2 macrophage-derived extracellular vesicle/polydopamine hydrogel attenuates diabetic periodontitis-induced bone loss via the NEK7/NLRP3/IL-1β pathway.

Yuzhao Cheng, Pengyu Zhao, Na Zhang, Jiehua Guo, Jiao Niu, Fenglan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuzhao Cheng *Shanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China.
Pengyu Zhao *Shanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China.
Na ZhangShanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China.
Jiehua GuoShanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China.
Jiao NiuShanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China.
Fenglan LiShanxi Medical University School and Hospital of Stomatology, Shanxi Medical University, Stomatology Department of Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China. 925777511@qq.com.

Funding

Natural Science Foundation of Shanxi Province 202403021222411Research Project of Shanxi Provincial Health Commission: Key Scientific and Technological Research Special Project No. 2025ZD014Shanxi Provincial Administration of Traditional Chinese Medicine 2024ZYY2C050Special Project for Scientific and Technological Cooperation and Exchange in Shanxi Province 202304041101037the Natural Science Foundation of Shanxi Province 202503021212367
6 · The paper itself

Abstract

The pathological progression of diabetic periodontitis is closely associated with macrophage functional imbalance induced by a high-glucose environment. High glucose significantly upregulates IL-1β and other pro-inflammatory factors by activating NLRP3 inflammasomes in macrophages, exacerbating periodontal tissue inflammation and suppressing osteoblast activity. Extracellular vesicles derived from M2-type macrophages (M2-EVs) effectively inhibit NLRP3 inflammasome activation and ameliorate macrophage polarisation imbalance through their natural inflammatory targeting affinity and miR-23a-3p-mediated negative regulation of NEK7. The M2-EVs/PDA/GelMA hydrogel developed in this study enables controlled release via a dynamic network structure, significantly reducing NLRP3 and IL-1β expression in periodontal tissues while promoting bone marrow stromal cell (BMSC) osteogenic differentiation through reparative macrophage-mediated secretion of osteoinductive factors, ultimately achieving periodontal bone repair and regeneration. This strategy establishes a novel multifunctional biomaterial platform for diabetic periodontitis treatment by integrating immune modulation and bone regeneration mechanisms, demonstrating significant potential for clinical translation.

Indexed as

Alveolar Bone LossDiabetes ComplicationsExtracellular VesiclesHydrogelsInterleukin-1betaMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinPeriodontitisAnimalsDiabetes Mellitus, ExperimentalInflammasomesMiceOsteogenesisSignal TransductionHydrogelsInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseBone repair and regenerationDiabetic periodontitisM2-EVsmiR-23a-3p

Identifiers

PMID41461893
PMCPMC12855963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.