Evidence map›Paper›PMID 41461868›Full record

ArticleScientific reports2025

Evaluating the appropriateness and safety of generative AI in delivering lifestyle guidance for atrial fibrillation patients.

Masahiro Makino, Wan Jou She, Panote Siriaraya, Satoaki Matoba, Keitaro Senoo

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masahiro MakinoDepartment of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Wan Jou SheFaculty of Information and Human Sciences, Kyoto Institute of Technology, Kyoto, Japan.
Panote SiriarayaFaculty of Information and Human Sciences, Kyoto Institute of Technology, Kyoto, Japan.
Satoaki MatobaDepartment of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Keitaro SenooDepartment of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. k-senoo@koto.kpu-m.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lifestyle factors play a major role in atrial fibrillation (AF) incidence, but the effectiveness of lifestyle counseling varies among individuals. Due to limited consultation time, physicians often provide only brief guidance, leaving patients to manage changes on their own. This study assessed the clinical utility of three Large Language Models (LLMs) for delivering accurate and personalized lifestyle guidance: (1) GPT-4o, (2) a retrieval-augmented model using a curated Q&A database (DB GPT), and (3) a modular RAG model retrieving evidence from PubMed (PubMed GPT). Sixty-six questions from 16 AF patients were categorized into exercise, diet, lifestyle, and other domains. Five experienced electrophysiologists independently evaluated LLM-generated lifestyle guidance and physician-provided counseling responses using ten dimensions. GPT-4o demonstrated a comparable level of scientific consensus to electrophysiologists, while achieving a lower error rate and significantly higher levels of specialized content, empathy, and helpfulness. DB GPT and PubMed GPT showed similar error rates, proportions of specialized content, empathy, and helpfulness compared to electrophysiologists, but exhibited strengths in specialized content in exercise-related and accuracy in diet-related dimensions. These findings suggest that integrating complementary model strengths may help develop safer and more reliable medical AI systems.

Indexed as

Artificial IntelligenceAtrial FibrillationLife StyleAgedCounselingExerciseFemaleHumansMaleMiddle AgedAtrial fibrillationGenerative AILarge language modelLifestyle guidanceRetrieval-augmented generation

Identifiers

PMID41461868
PMCPMC12855944

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.