ArticleScientific reports2025
Elevated lactate-to-albumin ratio predicts short- and long-term mortality in trauma and surgical intensive care patients: a retrospective MIMIC-IV cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- EarlyPostoperative Lactate-to-Preoperative Albumin Ratio with In-Hospital Mortality After Elective Colorectal Cancer Surgery: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Lactate to albumin ratio LAR predicts mortality in critically ill adults with asthma across two cohorts.Scientific reports · 2026Article
- Lactate-to-albumin ratio as an independent predictor of short- and long-term mortality in ICU patients with malignant tumors: A retrospective cohort study.Oncology letters · 2026Article
- Association of Early Postoperative Biochemical Markers with a Composite Adverse Perioperative Outcome After Bariatric Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Lactate to albumin ratio and 30-day mortality in ICU patients with influenza: a single-center retrospective cohort.Virology journal · 2026Observational
- Association between lactate to albumin ratio and 28-day all-cause mortality in patients with extracorporeal membrane oxygenation: a retrospective multi-cohort study.BMC cardiovascular disorders · 2026Article
- Serial lactate-procalcitonin interaction identifies a high-risk phenotype in 24-h conditional survivors of post-cardiac arrest syndrome: a CART-based analysis.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lactate-to-albumin ratio (LAR), as a composite biomarker of integrated metabolic stress and systemic inflammation, has demonstrated prognostic utility in critical illnesses like sepsis and acute pancreatitis. However, its role in surgical/trauma intensive care unit (SICU/TSICU) patients remains underexplored. This study aimed to investigate the relationship between LAR and mortality in SICU/TSICU patients. A retrospective cohort analysis was conducted using the MIMIC-IV database. Adult SICU/TSICU patients with lactate and albumin measurements within 24 h of admission were included. Exclusion criteria were: repeat ICU admissions, ICU stay < 24 h, and missing lactate or albumin data. Ultimately, 2,665 patients were categorized into quartiles based on LAR. Multivariable Cox regression, restricted cubic spline (RCS), and Kaplan-Meier analyses were employed to evaluate the relationship between LAR and 28-day and 365-day mortality. Subgroup and sensitivity analyses assessed interactions and robustness. The 28-day mortality and 365-day mortality rates reached 17.94% and 31.26%, respectively. Multivariate Cox proportional hazards analysis revealed that elevated LAR independently predicted higher mortality risks (adjusted HR = 1.26, 95% CI:1.19-1.33 for 28-day; HR = 1.20, 95% CI:1.14-1.26 for 365-day), with a dose-response relationship across quartiles (P for trend < 0.001). RCS analysis showed a nonlinear association between LAR and 28-day mortality (P for nonlinear = 0.032). The 365-day RCS analysis demonstrated a significant overall positive association between LAR and mortality risk (P for overall < 0.001). Subgroup analyses confirmed consistency and robustness. Elevated LAR shows significant association with both short- and long-term mortality in SICU/TSICU patients, suggesting potential utility as a complementary prognostic tool. Further validation is warranted before clinical implementation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.