Evidence map›Paper›PMID 41461814›Full record

ArticleScientific reports2025

Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer.

Siraprapa Siritutsoontorn, Preeyanuch Manohong, Natthapat Sawektreeratana, Chutima Kuhakarn, Kanlaya Prapainop Katewongsa, Sarawut Jitrapakdee

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siraprapa SiritutsoontornDepartment of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand.
Preeyanuch ManohongDepartment of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand.
Natthapat SawektreeratanaDepartment of Chemistry, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand.
Chutima KuhakarnDepartment of Chemistry, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand.
Kanlaya Prapainop KatewongsaDepartment of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand. kanlaya.pra@mahidol.ac.th.
Sarawut JitrapakdeeDepartment of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok, 10400, Thailand. sarawut.jit@mahidol.ac.th.

Funding

Program Management Unit for Human Resources & Institutional Development, Research and Innovation B38G670011]
6 · The paper itself

Abstract

Targeting cancer metabolism has become a promising strategy for cancer treatment. Pyruvate carboxylase (PC) is an anaplerotic enzyme that replenishes tricarboxylic acid cycle intermediates. PC is overexpressed in several types of human cancers, especially in aggressive cancers, including breast and colon cancer, where it promotes growth, survival, and metastasis. Recently, N

Indexed as

Breast NeoplasmsColonic NeoplasmsEnzyme InhibitorsLipogenesisNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerPyruvate CarboxylaseRiboflavinAntineoplastic AgentsCell Line, TumorCell ProliferationFemaleHCT116 CellsHT29 CellsHumansAntineoplastic AgentsEnzyme InhibitorsPolylactic Acid-Polyglycolic Acid CopolymerPyruvate CarboxylaseRiboflavinBreast cancerColon cancerNanoparticlesPLGAPyruvate carboxylaseZY-444

Identifiers

PMID41461814
PMCPMC12764468

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.