ArticleScientific reports2025
Oropharyngeal Helicobacter pylori colonization increases risk and worsens prognosis of head and neck squamous cell carcinoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) colonization in the oropharynx has been suggested to contribute to the development of head and neck squamous cell carcinoma (HNSCC), but prospective evidence remains limited. This prospective cohort study aimed to investigate the association between oropharyngeal H. pylori colonization, including its virulence gene types, and the risk and prognosis of HNSCC. A total of 220 high-risk individuals and 220 diagnosed HNSCC patients were enrolled. Oropharyngeal samples were collected for H. pylori detection by culture and quantitative PCR (qPCR). Virulence genes cagA and vacA were genotyped. Cox proportional hazards models assessed HNSCC incidence and overall survival, with Kaplan–Meier and log-rank tests evaluating survival differences. H. pylori positivity was significantly higher in the HNSCC group compared to the high-risk group (43.6% vs. 32.7%, P = 0.033). In high-risk individuals, H. pylori colonization was an independent risk factor for HNSCC onset (HR = 1.50, 95% CI: 1.02–2.21, P = 0.039), with higher bacterial loads and presence of high-virulence genotypes (e.g., cagA+/vacA s1/m1) linked to increased risk (P < 0.05). Among HNSCC patients, H. pylori-positive individuals showed higher recurrence (26.0% vs. 16.9%, P = 0.018) and mortality rates (13.5% vs. 8.1%, P = 0.043), with poorer overall survival (HR = 1.57, P = 0.035). Co-infection with HPV may further complicate the clinical profile, potentially involving the local immune microenvironment. Oropharyngeal H. pylori colonization, particularly by high-virulence strains, significantly elevates the risk of HNSCC development and worsens clinical outcomes. The interplay between H. pylori and HPV suggests the need for integrated pathogen screening and targeted interventions to improve early detection and individualized treatment strategies for HNSCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.