Evidence map›Paper›PMID 41461716›Full record

ArticleScientific reports2025

NHE1 in macrophages promotes octanal/Olfr2-induced atherosclerosis via calcium-dependent ROS and NLRP3 inflammasome activation.

Tianhui Wang, Lan Wang, Qian Tian, Yuan Zhu, Lijuan Shao, Jiao Zeng, Yongchao Yu, Zhonglian Li, Xiaomeng Su, Juhai Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianhui WangSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Lan WangSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Qian TianSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Yuan ZhuSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Lijuan ShaoSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Jiao ZengSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Yongchao YuSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Zhonglian LiSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Xiaomeng SuSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Juhai ChenSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Ya ZhangSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China.
Xiangang MoSchool of Clinical medicine, Guizhou Medical University, Guiyang, 550025, China. moxiangang123@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is the leading cause of global mortality and morbidity. Despite the elevated expression of sodium-hydrogen exchanger 1 (NHE1) and olfactory receptor 2 (Olfr2) in plaque macrophages, their interactions within the AS context remain poorly understood. In this study, ApoE

Indexed as

AtherosclerosisCalciumInflammasomesMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesSodium-Hydrogen Exchanger 1AnimalsMaleMiceMice, Inbred C57BLRAW 264.7 CellsCalciumInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen SpeciesSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1AtherosclerosisInflammationOctanalOlfactory receptor 2Sodium hydrogen exchanger 1

Identifiers

PMID41461716
PMCPMC12749899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.