ArticleScientific reports2025
Characterization of age-related dolichol increases in the retina of the C57BL/6 mouse.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Isoprene Units to Polyprenols and Dolichols: 70 Years of Polyisoprenoid Biosynthesis Research.Cell biochemistry and biophysics · 2026Review
Corrections and comments
- Update of
Authors and funding
4 authors.
Funding
Abstract
Dolichol is a lipid uniquely important for retinal cells. Mutations affecting dolichol biosynthesis cause non-syndromic retinal degeneration. Aging is a major risk factor for leading causes of vision loss. We characterized age-related changes in dolichol levels in the retinas of C57BL/6 mice of both sexes at the age of PD (postnatal day) 5, 10, 15, 20, 30, 60, 180, 360, and 600 using liquid chromatography-mass spectrometry (LC-MS), a highly sensitive and specific method for dolichol analysis. All four major dolichol species-dolichol-17 (Dol-17), Dol-18, Dol-19, and Dol-20, increased dramatically with age. The largest increase was in Dol-18, which rose by a factor of 100 from PD 5 to PD 600. Age-related dolichol increases occurred in two distinct phases: Phase I (PD 5 to PD 30) and Phase II (PD 30 to PD 600). These phases coincide with the phases of postnatal development and adult aging, respectively. A shift in the dolichol chain-length profile with age was also observed. Dol-19 was the dominant species from PD 5 to PD 15 but Dol-18 became dominant after PD 20. Changes in cholesterol and coenzyme Q9 (CoQ9) followed the same biphasic pattern. The age-related increase in dolichol levels may influence the physical properties of cell membranes, act as an ultraviolet (UV) filter for retinal cells, and serve as a biomarker of retinal aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.