Evidence for neuroprotection by Bacillus coagulans ATCC 7050 via synaptic plasticity and oxidative balance in Alzheimer's disease.

Mohammad Saremi, Samaneh Safari, Mohammad Yousef Alikhani, Alireza Komaki, Seyed Davar Siadat, Babak Asghari

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Saremi *Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Samaneh Safari *Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.

Mohammad Yousef AlikhaniDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Alireza KomakiDepartment of Neuroscience, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.

Seyed Davar SiadatDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Babak AsghariDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. bab.asghari@gmail.com.

Funding

Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences Grant Number: 140303292888

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic impairment, and oxidative stress. Probiotics with antioxidant and anti-inflammatory properties have been proposed as potential adjunctive strategies. This study examined whether oral administration of Bacillus coagulans ATCC 7050 could attenuate hippocampal oxidative stress, modulate synaptic plasticity, and influence spatial working memory in an Aβ

Indexed as

Alzheimer DiseaseBacillus coagulansNeuronal PlasticityNeuroprotectionOxidative StressProbioticsAmyloid beta-PeptidesAnimalsDisease Models, AnimalGlutathione PeroxidaseHippocampusLong-Term PotentiationMaleMalondialdehydeMemory, Short-TermRatsAmyloid beta-PeptidesGlutathione PeroxidaseMalondialdehydeSuperoxide DismutaseAlzheimer’s diseaseBacillus coagulansLong-term potentiationOxidative stressWorking memory

Identifiers

PMID41461684

DOI10.1038/s41598-025-28207-y

PMCPMC12748739

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.