ArticleJournal of Korean Neurosurgical Society2026
Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.
Article in Journal of Korean Neurosurgical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveEpendymomas is a rare brain tumor. Accumulative evidence has revealed that there are differences between pediatric and adult patients. However, the clinical features and survival prognosis of pediatric and adult patients with brainstem ependymomas remain unclear.
methodsPediatric and adult patients with brainstem ependymomas diagnosed between 2000 and 2021 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The clinical characteristics (age, sex, race, tumor size treatment methods, etc.) of the included patients were reviewed, and the survival analysis was estimated via the Kaplan-Meier method.
resultsA total of 701 patients, including 269 pediatric patients and 432 adult patients, were identified. The median age of pediatric patients is 3.0 years old and the adult patients is 46.0 years old. Compared with adult brainstem ependymomas, pediatric patients showed a higher prevalence of anaplastic ependymoma, larger tumor size, and more frequent receipt of gross total resection (GTR), radiation, and chemotherapy (all P<0.001). Cox regression analysis identified that black race (P=0.032), and chemotherapy (P=0.048) are independent risk factors for pediatric brainstem ependymomas, and aging (P<0.001), male (P=0.034), and black race (P=0.002) for adult brainstem ependymomas. Survival analysis showed that GTR combined with radiation had significant overall survival advantage compared with other treatment regimens in both pediatric and adult cohorts (P=0.045 and P=0.034, respectively).
conclusionThis study comprehensively investigated the clinical features and survival outcomes of patients with brainstem ependymomas, and identified several independent prognostic variables. The best recommended treatment method was GTR combined with radiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.