Evidence map›Paper›PMID 41460958›Full record

ArticleThe journal of physical chemistry. B2026

A Vibrational Analysis of Pyridoxal 5'-Phosphate Derivatives: Pyridoxal 5'-Phosphate-isopropylamine and Pyridoxal 5'-Phosphate-(

Ramandeep S Dosanjh, Stewart F Parker, Paul Collier, Ahir Pushpanath, Andrew P E York, Damian Grainger, Sanita B Tailor, Timothy Johnson, Timothy Hyde, Lachlan J N Waddell and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramandeep S DosanjhSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Stewart F ParkerSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.ORCID 0000-0002-3228-2570
Paul CollierJohnson Matthey Technology Centre, Blounts Court Road, Sonning Common, Reading RG4 9NH, U.K.
Ahir PushpanathJohnson Matthey, 28 Cambridge Science Park, Milton Road, Cambridge CB4 0FP, U.K.
Andrew P E YorkJohnson Matthey Technology Centre, Blounts Court Road, Sonning Common, Reading RG4 9NH, U.K.
Damian GraingerJohnson Matthey, 28 Cambridge Science Park, Milton Road, Cambridge CB4 0FP, U.K.
Sanita B TailorJohnson Matthey, 28 Cambridge Science Park, Milton Road, Cambridge CB4 0FP, U.K.
Timothy JohnsonJohnson Matthey Technology Centre, Blounts Court Road, Sonning Common, Reading RG4 9NH, U.K.ORCID 0000-0003-4651-7374
Timothy HydeJohnson Matthey Technology Centre, Blounts Court Road, Sonning Common, Reading RG4 9NH, U.K.
Lachlan J N WaddellSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Andrew SutherlandSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.ORCID 0000-0001-7907-5766
David LennonSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K.ORCID 0000-0001-8397-0528

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5'-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical production. To investigate the potential of vibrational spectroscopy to probe molecular interactions relevant to PLP's role as a cofactor in transamination reactions, two external aldimines, pyridoxal 5'-phosphate-isopropylamine (PLP-IPAm) and pyridoxal 5'-phosphate-(

Indexed as

PhenethylaminesPropylaminesPyridoxal PhosphateDensity Functional TheoryModels, MolecularSpectroscopy, Fourier Transform InfraredSpectrum Analysis, RamanVibrationPhenethylaminesPropylaminesPyridoxal Phosphate

Identifiers

PMID41460958
PMCPMC12794160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.