ArticlePloS one2025
Mapping the mortality-to-incidence ratios of Alzheimer's Disease and Related Dementias (ADRDs): Evidence from the South Carolina Alzheimer's disease registry.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
introductionMortality-to-incidence ratios (MIRs) are useful in assessing disease burdens and illustrating disparities. Unlike cancer, MIRs have not been applied to ADRDs. Therefore, we estimated and mapped the MIRs for ADRDs to show disparities in South Carolina.
methodsUsing data from the South Carolina Alzheimer's Disease Registry (2017-2021), ADRD MIRs were calculated by demographic and geospatial characteristics. To account for the influence of the COVID-19 pandemic, data from 2015 to 2019 were also examined. MIRs were calculated as age-adjusted mortality rates divided by age-adjusted incidence rates.
resultsOverall, Black people and rural individuals consistently experienced higher MIRs, with the COVID-19 pandemic increasing this disparity gap. MIRs greater than 1.00 were only observed among Black people. The MIR for 31 out of 46 counties exceeded the state average. DISCUSSION: Estimating and mapping ADRDs has aided in identifying specific areas with the greatest burden of ADRD in South Carolina for targeting interventions.
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