Evidence map›Paper›PMID 41460615›Full record

ArticleGeroScience2026

Dynamic brain functional connectivity in age-related hearing loss during auditory selective spatial attention.

Hongxing Liu, Yanru Bai, Mingkun Guo, Ran Zhao, Jianing Zhu, Guangjian Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongxing LiuAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.ORCID http://orcid.org/0000-0002-5144-4125
Yanru BaiAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.ORCID http://orcid.org/0000-0003-3959-7898
Mingkun GuoAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.ORCID http://orcid.org/0009-0008-7649-2642
Ran ZhaoAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.ORCID http://orcid.org/0000-0001-8240-1649
Jianing ZhuAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.ORCID http://orcid.org/0000-0002-0100-5562
Guangjian NiAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China. niguangjian@tju.edu.cn.ORCID http://orcid.org/0000-0002-9240-3020

Funding

Key Technologies Research and Development Program 2023YFF1203500National Natural Science Foundation of China 824B2056Seed Foundation of Tianjin University 2025XJ1-0006
6 · The paper itself

Abstract

Age-related hearing loss (ARHL) is a common health problem that impairs auditory perception. However, the dynamic patterns of brain functional connectivity in ARHL during auditory spatial selective attention have not been thoroughly investigated. In this study, 32 older adults were recruited to investigate the dynamic brain functional connectivity in ARHL. First, an experimental paradigm for auditory spatial selective attention was designed, and neural electrical signals were recorded using electroencephalography. Then, a multilayer time-varying brain network was constructed based on multiple time windows, equally dividing each epoch signal to capture dynamic functional connectivity across time scales. Finally, the core layer brain network was identified by the multilayer time-varying brain network properties to investigate the changing patterns of network topology. Behavioral analysis revealed a significant negative correlation between the severity of hearing loss and auditory spatial selective attention performance. Multilayer time-varying brain network analysis revealed that worsening hearing loss was found to lead to increased inter-layer connectivity strength, decreased multilayer modularity and a higher participation coefficient. This suggests that the brain compensates by weakening the independence of local functional modules and enhancing cross-interaction. Core layer analysis further highlighted the critical role of the right parietal lobe in auditory spatial selective attention. It also suggested that connectivity between the right prefrontal and frontal lobes may play a compensatory role in ARHL. In conclusion, these findings provide important neuroscientific insights into the dynamic brain functional connectivity of ARHL, and potential biomarkers and time windows for the development of precision auditory rehabilitation strategies.

Indexed as

AttentionAuditory PerceptionBrainPresbycusisAgedBrain MappingElectroencephalographyFemaleHumansMaleNerve NetAge-related hearing lossAuditory selective spatial attentionBrain functional connectivityElectroencephalogramMultilayer time-varying brain network

Identifiers

PMID41460615
PMCPMC13638867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.