Evidence map›Paper›PMID 41460594›Full record

ArticleNeurochemical research2025

Schisanhenol Inhibits MPTP/MPP

Guanghui Dong, Li Fan, Chengchong Li, Yu Jiao, Xiaoming Li, Honglong Li, Yina Liang, Yandong Ren, Lihong Wang, Dan Xiao and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guanghui DongDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, 161006, China.
Li FanThe Institute of Medicine, Qiqihar Medical University, Qiqihar, 161006, China.
Chengchong LiDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Yu JiaoDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Xiaoming LiThe Institute of Medicine, Qiqihar Medical University, Qiqihar, 161006, China.
Honglong LiDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Yina LiangDepartment of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China.
Yandong RenDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Lihong WangDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Dan XiaoDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Jian XiaoDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China.
Tong WuDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China. wutong21th@126.com.
Libo LiDepartment of Mental Health, Qiqihar Medical University, Qiqihar, 161006, China. liliboqqhr@163.com.

Funding

General Program of Qiqihar Academy of Medical Sciences QMSI2024M-13Heilongjiang Province Natural Science Foundation of China LH2021H126Key cultivation program of Qiqihar Academy of Medical Sciences 2022-ZDPY-008
6 · The paper itself

Abstract

Schisanhenol (Sal) is a lignan component derived from the traditional Chinese medicine Schisandra rubrifora (Franch.). Pharmacological research has highlighted that Sal exhibits pronounced neuroprotection against oxidative stress-triggered damage. An in vivo mice model of Parkinson's disease (PD) was developed using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and in vitro studies employed 1-methyl-4-phenylpyridinium (MPP

Indexed as

Dopaminergic NeuronsFerroptosisLignans1-Methyl-4-phenylpyridiniumAnimalsCell Line, TumorCell SurvivalHumansMaleMiceMice, Inbred C57BLNeuroprotective AgentsNF-E2-Related Factor 2Parkinson DiseasePhospholipid Hydroperoxide Glutathione PeroxidaseSignal Transduction1-Methyl-4-phenylpyridiniumglutathione peroxidase 4, mouseLignansNeuroprotective AgentsNfe2l2 protein, mouseNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseFerroptosisMPTP/MPP+Nrf2/TrxR1/GPX4 pathwayParkinson’s diseaseSchisanhenol

Identifiers

PMID41460594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.