ArticleJapanese journal of radiology2026
Diagnostic performance of digital markings on head computed tomography for evaluating intracranial hypertension in neonates and infants.
Article in Japanese journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the diagnostic performance of digital markings appearing on head computed tomography (CT): CT digital markings to evaluate intracranial hypertension (ICH) in neonates and infants. MATERIALS AND
methodsWe retrospectively selected 270 consecutive pediatric patients (163 males and 107 females) aged 0–23 (8.0 ± 7.7) months, who underwent head CT at our institution from April 2009 to April 2023. Two board-certified observers evaluated the presence of CT digital markings, which are defined as focal depressions of inner table of the cranial bone, on CT images with reconstructed slice thickness ranging from 0.5 to 1 mm at the bone window setting. Generated volume rendering (VR) and ray-sum images were used as references. A board-certified pediatrician and ophthalmologist reviewed patients’ medical records and assessed the presence of ICH. Chi-square test was used to evaluate the relationship between CT digital markings and ICH in all patients, patients aged < 1 year, and 1 year old patients. A p value < 0.05 was considered as statistically significant. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were also calculated, according to each comparison.
resultsA total of 47 patients had ICH, and 128 patients demonstrated digital markings. There were no significant correlations between CT digital markings and ICH in all patients, patients aged < 1 year, or patients aged 1 year (p = 0.63, 0.38, and > 0.99, respectively). Sensitivity, specificity, PPV, and NPV were 0.51, 0.54, 0.19, and 0.84 for all patients; 0.51, 0.56, 0.24, and 0.81 for patients aged < 1 year old; and 0.50, 0.48, 0.08, and 0.92 for patients aged 1 year old, respectively.
conclusionDigital markings on head CT observed in neonates and infants are not associated with ICH and thus not clinically useful for the diagnosis of ICH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.