Evidence map›Paper›PMID 41460376›Full record

ArticleMolecular biology reports2025

Functional genetic variants in immune-checkpoint molecules and susceptibility to Nasopharyngeal carcinoma in a Tunisian case-control study.

Wejden Gharbi, Wicem Siala, Olfa Abida, Bassem Lahiani, Sawsan Feki, Ikram Ben Amor, Jamel Daoud, Hatem Masmoudi, Hend Hachicha

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wejden GharbiAutoimmunity, Cancer, and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia. gharbi.wejden1995@gmail.com.ORCID http://orcid.org/0009-0008-6230-6116
Wicem SialaDepartment of Cancer Radiotherapy, Habib Bourguiba University Hospital, Sfax, Tunisia.
Olfa AbidaAutoimmunity, Cancer, and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.
Bassem LahianiDepartment of Cancer Radiotherapy, Habib Bourguiba University Hospital, Sfax, Tunisia.
Sawsan FekiAutoimmunity, Cancer, and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.
Ikram Ben AmorThe Regional Blood Transfusion Center of Sfax, Sfax, Tunisia.
Jamel DaoudDepartment of Cancer Radiotherapy, Habib Bourguiba University Hospital, Sfax, Tunisia.
Hatem MasmoudiAutoimmunity, Cancer, and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.
Hend HachichaAutoimmunity, Cancer, and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune checkpoint pathways regulating T cell activity are key targets in cancer therapy. Genetic variations in checkpoint molecules (CTLA-4, PD-1, PD-L1) can alter signaling pathways, affecting cancer risk and treatment response in various types of malignancies.

methodsThis study aimed to investigate associations between common polymorphisms in immune-regulating genes (CTLA-4, PDCD1 and CD274) and susceptibility to nasopharyngeal carcinoma (NPC) in the Tunisian population. We analyzed six polymorphisms: rs231775 and rs3087243 (CTLA-4), rs2227981, rs2227982, and rs36084323 (PDCD1), and rs2890658 (CD274) in a case-control study which enrolled 61 Tunisian NPC patients and 150 matched healthy controls using the PCR-RFLP method.

resultsFor the rs231775 SNP, our findings showed a significant association between the AA genotype and increased NPC susceptibility in the recessive model (GG + AG vs. AA) (p

conclusionOur results suggest that the CTLA-4_rs231775 > AA and CD274_rs2890658 > CC genotypes could be considered as predisposition factors for NPC. These findings could pave the way for future investigations into NPC pathogenesis and assessing CTLA-4, PDCD1, and CD274 as personalized therapeutic targets.

Indexed as

CTLA-4 AntigenImmune Checkpoint ProteinsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdultAgedB7-H1 AntigenCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedB7-H1 AntigenCD274 protein, humanCTLA-4 AntigenCTLA4 protein, humanImmune Checkpoint ProteinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCheckpoint moleculesGene susceptibilityNasopharyngeal carcinomaPersonalized immunotherapy

Identifiers

PMID41460376

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