Evidence map›Paper›PMID 41460344›Full record

ArticleCellular and molecular life sciences : CMLS2025

VAMP4 in hypoxic adipose stem cell exosomes alleviates ischemia-reperfusion injury.

Yinmin Wang, Shun Yu, Xiuxia Wang, Rui Jin, Fei Liu, Jun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yinmin Wang *Department of plastic and reconstructive surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China. wangyinmin@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-9733-8742
Shun Yu *Department of plastic surgery, Affiliated hospital of Jiangnan University, Wuxi, Jiangsu, China.
Xiuxia WangDepartment of plastic and reconstructive surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Rui JinDepartment of plastic and reconstructive surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Fei LiuDepartment of plastic and reconstructive surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Jun YangDepartment of plastic and reconstructive surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.

Funding

National Nature Youth Foundation of China 82402938Science and Technology Commission of Shanghai Municipality 22MC1940300Wuxi Taihu Lake Talent Plan, Supports for Leading Talents in Medical and Health Profession Wuxi Taihu Lake Talent Plan, Supports for Leading Talents in Medical and Health Profession
6 · The paper itself

Abstract

backgroundIschemia/reperfusion injury (I/RI) impedes the progress of flap and allograft transplantation. Among various strategies to address oxidative stress (OS) and mitochondrial dysfunction associated with I/RI, exosomes derived from adipose-derived stem cells (ADSCs) subjected to hypoxia pretreatment show significant therapeutic potential. METHODS AND

resultsThis study assessed the effects of ADSC-derived exosomes (ADSC-Ex) from normoxic and hypoxic conditions on reactive oxygen species (ROS), mitochondrial calcium ion (Ca

conclusionThis study demonstrated that hypoxic ADSC-Ex reduced ROS and mitochondrial dysfunction in vascular endothelial cells through VAMP4, thereby attenuating I/RI. This finding might provide a new approach for treating post-transplant I/RI.

Indexed as

Adipose TissueExosomesReperfusion InjuryStem CellsAnimalsApoptosisCalciumCell HypoxiaCells, CulturedHumansHuman Umbilical Vein Endothelial CellsMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondriaCalciumReactive Oxygen SpeciesAdipose derived stem cellExosomesHypoxiaIschemia/reperfusion injury (I/RI)Mass spectrometryMitochondria

Identifiers

PMID41460344
PMCPMC12748495

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.