Evidence map›Paper›PMID 41460316›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Development and optimization of asiaticoside co-crystal-loaded transdermal patch for topical therapy.

Suhas Shivaji Siddheshwar, Omkar Atkare, Arti Changdev Ghorpade, Rajashri Ghogare, Someshwar Dattatraya Mankar

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suhas Shivaji SiddheshwarDepartment of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, Maharashtra, India. drssiddheshwar@gmail.com.ORCID http://orcid.org/0000-0002-7944-9470
Omkar AtkareDepartment of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, Maharashtra, India.ORCID http://orcid.org/0009-0002-2647-9534
Arti Changdev GhorpadeDepartment of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, Maharashtra, India.ORCID http://orcid.org/0009-0003-7843-5688
Rajashri GhogareDepartment of Pharmacology, Pravara Rural College of Pharmacy, Loni, Maharashtra, India.ORCID http://orcid.org/0000-0002-7364-4929
Someshwar Dattatraya MankarDepartment of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, Maharashtra, India.ORCID http://orcid.org/0000-0003-3991-9412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to develop and optimize a transdermal patch incorporating asiaticoside co-crystals to enhance solubility, mechanical properties, and sustained release for effective topical therapy in wound management. Asiaticoside co-crystals were prepared by the solvent evaporation method using ethanol-water (70:30) with succinic acid (1:1 molar ratio) as co-former and incorporated into hydrogel-based transdermal patches using HPMC K100M and PEG 400. A 3

Indexed as

Transdermal PatchTriterpenesAdministration, CutaneousAnimalsCrystallizationDelayed-Action PreparationsDrug LiberationExcipientsHydrogelsHypromellose DerivativesMalePolyethylene GlycolsRatsSkinSkin AbsorptionSolubilityasiaticosideDelayed-Action PreparationsExcipientsHydrogelsHypromellose Derivativespolyethylene glycol 400Polyethylene GlycolsTriterpenes32 factorial designAsiaticosideCo-crystalsSkin irritationStability studyTransdermal patchWound healing

Identifiers

PMID41460316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.