Evidence map›Paper›PMID 41460304›Full record

ReviewAmerican journal of clinical dermatology2026

Emerging Treatments in Pemphigus: Is Healing an Achievable Goal?

Barbara Horváth, Marjolein A J Hiel, Anne-Lise Strandmoe, Joost M Meijer

Abstract readReview
PubMed Publisher
In one paragraph

Review in American journal of clinical dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Barbara HorváthDepartment of Dermatology, Centre of Expertise for Blistering Diseases, European Reference Network for Rare Skin Diseases (ERN SKIN), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. b.horvath@umcg.nl.ORCID http://orcid.org/0000-0001-8559-3674
Marjolein A J HielDepartment of Dermatology, Centre of Expertise for Blistering Diseases, European Reference Network for Rare Skin Diseases (ERN SKIN), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-7715-1697
Anne-Lise StrandmoeDepartment of Dermatology, Centre of Expertise for Blistering Diseases, European Reference Network for Rare Skin Diseases (ERN SKIN), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0009-0000-0648-5043
Joost M MeijerDepartment of Dermatology, Centre of Expertise for Blistering Diseases, European Reference Network for Rare Skin Diseases (ERN SKIN), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-7654-3528

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus is a group of rare autoimmune blistering disorders affecting the skin and mucosal surfaces, caused by pathogenic immunoglobulin G (IgG) autoantibodies targeting desmosomal cadherins, specifically desmoglein-1 and desmoglein-3, which are key components of desmosomes. There are two main forms of pemphigus: pemphigus vulgaris (PV) and pemphigus foliaceus (PF), with PV being the most common. Pemphigus can be life-threatening owing to the progressive loss of the epidermal and epithelial barrier function. However, the introduction of rituximab, an anti-CD20 monoclonal antibody, has significantly improved treatment outcomes in pemphigus. This review provides a comprehensive overview of the current treatment landscape for pemphigus, highlighting both established and emerging therapeutic approaches.

Indexed as

PemphigusAutoantibodiesDesmoglein 1Desmoglein 3HumansRituximabSkinTreatment OutcomeAutoantibodiesDesmoglein 1Desmoglein 3Rituximab

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.