Evidence map›Paper›PMID 41460253›Full record

Trial reportWorld journal of urology2025

Enhanced versus extended preoperative antibiotic prophylaxis for retrograde intrarenal surgery in high infectious risk patients: a randomized controlled trial.

Amr A Elsawy, Ehab A Nour, Adel Nabeeh, Ahmed R El-Nahas

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05384197 (Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05384197 phase3unknown statusnot on this map

Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients: Randomized Controlled Trial

TypeinterventionalSponsorMansoura UniversityRan2022 to 2023Enrolled280ConditionsRenal StoneArmsEnhanced regimen, Extended regimen
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Amr A ElsawyUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt. amrelsawy.unc@hotmail.com.ORCID http://orcid.org/0000-0001-7077-8094
Ehab A NourUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Adel NabeehUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Ahmed R El-NahasUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare enhanced (2 days) antibiotic prophylaxis (AP) versus extended (7 days) AP in terms of rate and grade of infectious complications post RIRS in high-risk patients. In addition, we aimed to identify the risk factors related to these devastating complications. PATIENTS AND

methodsAfter institutional review board (IRB) approval, 145 patients were randomized into two groups; enhanced and extended groups. Baseline clinical, laboratory and radiological characteristics were compared between the two groups. Primary outcome was incidence of post-RIRS infectious complications. Secondary outcomes comprised length of hospital stay, stone free rate (SFR), unplanned visits and hospital readmissions. Univariate and multivariate logistic regression analyses were utilized to identify independent predictors of post-RIRS infectious complications.

resultsThe two study groups were comparable for preoperative baseline patients’ and stone characteristics. Asymptomatic bacteriuria, diabetes mellitus and lengthy dwelling ureteral stents were identified in 66 (45.5%), 51 (35%) and 113 (78%) patients, respectively. The rate of post-RIRS infectious complications was comparable between the two groups (36% in enhanced group and 24% in extended group, P = 0.81). There were no differences between the two groups in terms of grade of infectious complications or infected postoperative urine culture (P = 0.74, and 0.06, respectively). Length of stay, SFR and unplanned visits and hospital readmissions were statistically comparable between the two groups. On multivariate analysis, only preoperative pyuria and lengthy dwelling ureteral stents were independently associated with increased risk of post-RIRS infectious complications regardless the AP duration (relative risk 95%CI, p value = 1.49 1.22–1.83, 0.01 and 1.42 1.15–1.76, 0.02, respectively).

conclusionsPrior to RIRS in high-risk patients for infectious complications, enhanced (2 days) AP was shown comparable to extended (7 days) AP in terms of rate and grade of infectious post-operative events. Preoperative pyuria and lengthy dwelling ureteral stents were independent risk factors for post-RIRS infectious complications regardless the AP duration.

trial registrationClinicaltrials.gov ID: NCT05384197.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisKidney CalculiPostoperative ComplicationsPreoperative CareUreteroscopyUrinary Tract InfectionsAdultFemaleHumansIncidenceLength of StayMaleMiddle AgedRisk FactorsTime FactorsAnti-Bacterial AgentsAntibiotic prophylaxisFlexible ureteroscopyInfectious complicationsRetrograde intrarenal surgerySepsis

Identifiers

PMID41460253
PMCPMC12748131

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.