ArticleAnalytical chemistry2026
Engineered Reactive Interfaces Enable Mass Spectrometry Imaging of Multiple Thiols for Decoding PFOS-Induced Redox Dysregulation.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Spatial profiling of multiple thiols shows great significance in elucidating the redox status across tissue microregions and understanding the molecular mechanisms of oxidative stress injury. Traditional matrix-assisted laser desorption/ ionization mass spectrometry imaging (MALDI MSI) relies on chemical derivatization for thiol visualization, but multistep derivatization protocols and nonspecific matrix-adduct formation compromise both detection sensitivity and spatial mapping fidelity. Herein, we engineer a reactive interface-assisted chemical derivatization platform for sensitive assessment of multiple thiols in various tissues via forming the "matrix-tissue-interface" sandwich structure. Reactive interface that predeposited with
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