Evidence map›Paper›PMID 41460143›Full record

ArticleIndian journal of ophthalmology2026

Revolutionizing tear trough rejuvenation: A novel bilaminar approach with differential rheologic G prime fillers.

Debraj Shome, Suhina Parkar, Riya Shahare, Depti Bellani, Ashwin Prabhughate, Jetal Thakur, Kodam Narasimha, Rinky Kapoor

Abstract read
In one paragraph

Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Debraj ShomeDepartment of Facial Plastic Surgery and Facial Cosmetic Surgery, The Esthetic Clinics®, Mumbai, Maharashtra, India.
Suhina ParkarDepartment of Research, The Esthetic Clinics Clinical Research organization, Mumbai, Maharashtra, India.
Riya ShahareDepartment of Research, The Esthetic Clinics Clinical Research organization, Mumbai, Maharashtra, India.
Depti BellaniDepartment of Research, The Esthetic Clinics Clinical Research organization, Mumbai, Maharashtra, India.
Ashwin PrabhughateDepartment of Research, The Esthetic Clinics Clinical Research organization, Mumbai, Maharashtra, India.
Jetal ThakurClinical Fellow, The Esthetic Clinics®, Mumbai, Maharashtra, India.
Kodam NarasimhaClinical Fellow, Department of Facial Plastic Surgery and Facial Cosmetic Surgery, The Esthetic Clinics®, Mumbai, Maharashtra, India.
Rinky KapoorDepartment of Dermatology, Cosmetic Dermatology & Dermato-Surgery. The Esthetic Clinics®, Mumbai, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFacial aging, marked by soft tissue atrophy, ptosis, and midfacial structural changes, has amplified the role of dermal fillers in modern aesthetic practice. The bilaminar injection technique leverages the distinct rheological properties of high and low G prime hyaluronic acid fillers to enable dual-plane facial rejuvenation-deep structural support and superficial contour refinement. This case series investigates the clinical efficacy and safety of this technique in correcting tear trough deformities.

methodsThe study was conducted in a single-center institutional aesthetic setting. Five patients (aged 25-60 years) presenting with midface volume loss and tear trough concerns for both the eyes were included following clinical assessment. Randomization and masking were not applied due to the nature of the procedure. A bilaminar approach was adopted: high G prime fillers were injected supraperiosteally to reinforce & augment deep structures, while low G prime fillers were deposited subdermally for fine contouring. All procedures were performed under aseptic conditions using a combination of needle and cannula techniques.

resultsPrimary outcomes included periorbital volume restoration and contour correction assessed at a 2-week follow-up. Adverse events and patient satisfaction (measured via visual analog scale) were also documented for 3-6 months. All patients exhibited visible improvement in midface volume and tear trough contour, with high satisfaction scores. Transient ecchymosis and edema were the only noted minor side effects.

conclusionThe bilaminar technique offers a precise, anatomically harmonious, and well-tolerated approach to tear trough rejuvenation, establishing itself as a sophisticated tool in advanced facial aesthetics.

Indexed as

Cosmetic TechniquesDermal FillersEyelidsHyaluronic AcidRejuvenationSkin AgingAdultFemaleFollow-Up StudiesHumansInjections, IntradermalMaleMiddle AgedPatient SatisfactionRheologyDermal FillersHyaluronic AcidBilaminar techniquehigh G prime fillerlow G prime fillertear troughunder eye dark circle

Identifiers

PMID41460143
PMCPMC12867301

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.