Evidence map›Paper›PMID 41460133›Full record

ArticleIndian journal of ophthalmology2026

Optical coherence tomography features of the graft-host junctions after deep anterior lamellar keratoplasty: Long-term changes.

Burcin Kepez Yildiz, Farida O Elzawahry, Frederick Beer, Fatima Habroosh, Luca Marelli, Supanuch Siriviboonchaiyakul, Harminder S Dua, Dalia G Said

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Burcin Kepez YildizAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Farida O ElzawahryAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Frederick BeerAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Fatima HabrooshAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Luca MarelliAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Supanuch SiriviboonchaiyakulAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Harminder S DuaAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.
Dalia G SaidAcademic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe wound healing process in the graft-host junction (GHJ) after deep anterior lamellar keratoplasty (DALK) can affect the outcome. We studied the anterior segment optical coherence tomography (OCT) features of the GHJ in the early and late postoperative stages.

methodsOCT scans for 45 eyes of 43 patients within 4 weeks of DALK between 2014 and 2023 were retrospectively examined. Sixteen of these had a second scan 2 years or later postsurgery. GHJ profile, thickness, suture tracks, alignment (steps and shelves), and epithelial changes were examined and compared between early and late scans.

resultsThe GHJ profile at 2 to 4 weeks postoperative was perpendicular (7 eyes, 43.7%), zigzag (4 eyes), C shaped (4 eyes), or mixed (1 eye). These profiles were persistent in most of the eyes (13 eyes, 81.2%) in the late scans. The thickest region was predominantly in the graft (13 eyes, 81.2%). This disparity disappeared in the late scans. Suture tracks were seen as hyper-reflective lines which remained visible in the late scans even after suture removal. Five eyes (31.2%) had anterior and 1 eye (0.6%) had posterior graft steps which disappeared in the late scans. Host shelves were seen in 43.3% in the first scan, and all of them had disappeared or became attenuated in the late scan.

conclusionsThese findings can help surgeons assess their technique to reduce misalignment which could influence the outcomes and improve the understanding of the effect of the wound healing process in the GHJ.

Indexed as

Corneal DiseasesCorneal TransplantationTomography, Optical CoherenceWound HealingAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTime FactorsVisual AcuityYoung AdultDALKgraft–host junctionmisalignmentOCT

Identifiers

PMID41460133
PMCPMC12867292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.