Evidence map›Paper›PMID 41460102›Full record

ArticleAntimicrobial agents and chemotherapy2026

NDM-63: a novel NDM metallo-β-lactamase variant in the L3 loop, from a

Selene Rebecca Boncompagni, Alberto Antonelli, Benedetta Casciato, Filippo Pieralli, Alejandro J Vila, Diego M Moreno, Tommaso Giani, Gian Maria Rossolini

Abstract read
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In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Selene Rebecca BoncompagniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID 0009-0002-4807-4343
Alberto AntonelliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Benedetta CasciatoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Filippo PieralliEmergency and Internal Medicine Department, Careggi University Hospital, Florence, Italy.
Alejandro J VilaFacultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.ORCID 0000-0002-7978-3233
Diego M MorenoFacultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.ORCID 0000-0001-5493-8537
Tommaso GianiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID 0000-0001-7293-058X
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID 0000-0002-9386-0434

Funding

Ministero dell'Università e della Ricerca 2022WBPFSCMinistero dell'Università e della Ricerca CUP B93C22000920001
6 · The paper itself

Abstract

NDM-type metallo-β-lactamases (MBLs) are among the most widespread acquired carbapenemases in carbapenem-resistant Enterobacterales. As with other β-lactamases, allelic variability occurs among NDM-type MBLs, with almost 100 variants so far reported, differing by single or multiple amino acid substitutions or insertions, which may have implications for enzymatic activity. In this study, we report on a novel NDM variant, NDM-63, identified in a carbapenem-resistant ST147

Indexed as

beta-LactamasesKlebsiella pneumoniaeAmino Acid SubstitutionAnti-Bacterial AgentsBacterial ProteinsCarbapenemsCefepimeEscherichia coliHumansKlebsiella InfectionsMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-LactamasesCarbapenemsCefepimecarbapenemaseenzyme variantKlebsiella pneumoniaeNew-Delhi metallo-β-lactamase

Identifiers

PMID41460102
PMCPMC12888852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.