Evidence map›Paper›PMID 41459964›Full record

ArticlemBio2026

Epoxytiglianes potentiate the activity of colistin against resistant

Manon F Pritchard, Wenya Xue, Jingxiang Wu, Francesca Boardman, Mei Li, Yuqing Zhou, Saira Khan, Lydia C Powell, Joana Stokniene, Josh Davies-Jones and 8 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Manon F Pritchard *Advanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-5135-4744
Wenya Xue *Advanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-6842-1288
Jingxiang WuAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0009-0008-8907-7368
Francesca BoardmanAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0009-0005-9917-061X
Mei LiIneos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0009-0008-6013-9211
Yuqing ZhouIneos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0009-0003-3613-4027
Saira KhanAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-3284-3198
Lydia C PowellAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-8641-0160
Joana StoknieneQBiotics Group Ltd., Yungaburra, Australia.ORCID 0000-0002-8836-4209
Josh Davies-JonesSchool of Chemistry, Cardiff Catalysis Institute, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-9967-5467
Philip R DaviesSchool of Chemistry, Cardiff Catalysis Institute, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0003-4394-766X
Niklaas J BuurmaPhysical Organic Chemistry Centre, School of Chemistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0003-0260-5057
Georgina E MenziesSchool of Biosciences, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-6600-6507
Owen B SpillerMedical Microbiology, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-9117-6911
Timothy R WalshIneos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4315-4096
Paul ReddellQBiotics Group Ltd., Yungaburra, Australia.ORCID 0000-0002-0993-8957
Katja E HillAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-8590-0117
David W ThomasAdvanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0001-7319-5820

Funding

European Regional Development Fund 515454
6 · The paper itself

Abstract

The unrestricted use of colistin in animal husbandry has led to the emergence of mobile plasmid-borne colistin resistance ( IMPORTANCE: Resistance to colistin, an antibiotic of last resort for hard-to-treat infections, is on the increase. Therefore, the need to develop new antimicrobials to tackle antimicrobial resistance is of paramount importance. The epoxytiglianes represent an exciting range of molecules with a diverse range of biological effects in human and veterinary applications, including antimicrobial properties. In this study, we show how EBC-1013 interacts with the outer surface of colistin-resistant

Indexed as

Anti-Bacterial AgentsBacterial Outer MembraneCell MembraneColistinDrug Resistance, BacterialEscherichia coliBiofilmsDrug SynergismMicrobial Sensitivity TestsMolecular Dynamics SimulationAnti-Bacterial AgentsColistinantimicrobial resistance (AMR)mcr-1mcr-3plasmid

Identifiers

PMID41459964
PMCPMC12892952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.