Evidence map›Paper›PMID 41459945›Full record

ArticleJournal of virology2026

Characterizing a newly identified avian herpesvirus-specific gene SORF3 in DPV and its roles in potential pathogenicity.

Zihang Wang, Huijun Cao, Mingshu Wang, Anchun Cheng, Qiao Yang, Bin Tian, Xumin Ou, Di Sun, Yu He, Zhen Wu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Zihang Wang *College of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.ORCID 0009-0001-4235-4590
Huijun Cao *College of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Mingshu Wang *College of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Anchun ChengCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.ORCID 0000-0001-6093-353X
Qiao YangCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Bin TianCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Xumin OuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Di SunCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Yu HeCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Zhen WuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Xinxin ZhaoCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Ying WuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Shaqiu ZhangCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Juan HuangCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Yanlin YuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Ling ZhangCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Renyong JiaCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.
Mafeng LiuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.ORCID 0000-0002-6834-3128
Dekang ZhuCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.ORCID 0000-0002-7314-1088
Shun ChenCollege of Veterinary Medicine, Sichuan Agricultural University, Institute of Veterinary Medicine and Immunology, Research Center of Avian Disease, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duck plague virus (DPV) is a highly pathogenic avian herpesvirus that affects ducks, geese, and other anseriform poultry. The primary pathological changes observed in infected animals are mucosal, serosal, and systemic hemorrhages accompanied by exceptionally high fatality rates. While most DPV genes are conserved among herpesviruses, a small subset of genes, including the SORF3 gene, is unique to avian herpesviruses. To date, reports on the function and characteristics of the SORF3 gene are limited. In this study, the use of a polyclonal antibody against SORF3 demonstrated that this open reading frame could encode proteins. Through the use of DNA and protein synthesis inhibitors in infected cells, we delineated the gene's transcriptional and translational timeline, establishing SORF3 as a late gene. To further investigate the role of the protein encoded by the SORF3 gene in the pathogenic mechanism, we constructed a virus lacking the SORF3 gene. The growth kinetics results indicated that the SORF3 protein is not essential for viral replication.

Indexed as

Herpesviridae InfectionsPoultry DiseasesViral ProteinsAnimalsDucksVirulenceVirus ReplicationViral Proteinsduck plaguepathogenic mechanismSORF3specific gene

Identifiers

PMID41459945
PMCPMC12911913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.