ArticleAsian Pacific journal of cancer prevention : APJCP2025
Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDNA damage and repair (DDR) mechanisms are crucial for maintaining genomic stability by counteracting genetic insults that occur continuously in living organisms. Impairments in DDR pathways can lead to the accumulation of mutations and contribute to carcinogenesis. Lung cancer (LC) remains one of the most prevalent and lethal malignancies worldwide, affecting both men and women. This study aimed to investigate the association between the RAD51 -4719A/T (rs2619679) single nucleotide polymorphism (SNP) and lung cancer susceptibility. It also examined the correlation between RAD51 SNP genotypes and demographic, clinical, and pathological features in a cohort of Iraqi patients. MATERIALS AND
methodsThis case-control study consisted of fifty healthy individuals and one hundred and five lung cancer patients. Genotyping of the RAD51 gene -4719A/T polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
resultsLung cancer was significantly more frequent among older patients (aged 60-69 years), males, and smokers (p ≤ 0.01). A statistically significant association was found between the RAD51 -4719A/T polymorphism and lung cancer risk. Individuals carrying the AT and TT genotypes were observed to have a significantly higher frequency of lung cancer compared to those with the AA genotype, highlighting the potential role of this polymorphism in disease susceptibility (χ² =127.68, p =0.00000001). Furthermore, the T allele of this SNP was found to be significantly more frequent in lung cancer patients than in controls (p = 0.00000001), suggesting a potential role in increased genetic susceptibility to lung cancer.
conclusionsThis study is among the first to investigate the -4719A/T (rs2619679) polymorphism in the RAD51 gene and its association with lung cancer in the Iraqi population. A statistically significant association was identified between this variant and lung cancer risk. The genotypic patterns identified suggest that the presence of the T allele particularly in the more frequently occurring heterozygous AT genotype may contribute to the molecular mechanisms involved in lung cancer development through its impact on DNA repair processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.