ArticleAsian Pacific journal of cancer prevention : APJCP2025
Isolation and Characterization of Superoxide Dismutase from Tectus dentatus Marine Snail with Antimicrobial and Antitumor Activities.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.Scientific reports · 2026Article
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8 authors.
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Abstract
objectiveThe aim of this study is to reports the purification, biochemical characterization, and biological activities of superoxide dismutase (SOD) isoenzymes from the marine snail Tectus dentatus (TdSOD).
methodsThe enzyme was purified through DEAE-cellulose ion-exchange and Sephacryl S-300 size-exclusion chromatography, yielding two distinct isoenzymes, TdSOD1 and TdSOD2. TdSOD1 was further purified to homogeneity with a 6.9-fold purification and a specific activity of 658.3 U/mg.
resultsElectrophoretic analyses confirmed the enzyme's purity and revealed a native molecular weight of approximately 180 kDa, composed of subunits around 90 kDa. TdSOD1 showed optimal activity at pH 7.8 and was strongly activated by Zn²⁺ and Cu²⁺, while inhibitors such as KCN and H₂O₂ significantly reduced its activity. Functionally, TdSOD1 demonstrated notable antimicrobial activity, especially against Candida albicans (97.3% inhibition) and Gram-negative bacteria including Pseudomonas aeruginosa (61.7%) and Escherichia coli (60.2%). Lower activity was observed against Klebsiella pneumoniae (39.1%) and Staphylococcus aureus (2.9%). In anticancer assays, TdSOD1 exerted a dose-dependent cytotoxic effect on MCF-7 and MDA-MB-231 breast cancer cell lines, with an IC₅₀ of 33.42 µg/mL for MDA-MB-231 cells.
conclusionThese results suggest that TdSOD1 possesses promising antimicrobial and anticancer potential, supporting its future exploration as a multifunctional therapeutic agent.
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