Evidence map›Paper›PMID 41459828›Full record

ArticleChemSusChem2026

Aldehyde Electrophilicity and Ring Strain Govern Xylose Acetalization Pathways for Biobased Chemical Production.

Zezhong John Li, Deep M Patel, Songlan Sun, Claire L Bourmaud, Tso-Hsuan Chen, Dionisios G Vlachos, Jeremy S Luterbacher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemSusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zezhong John LiLaboratory of Sustainable and Catalytic Processing (LPDC), Institute of Chemicals Sciences and Engineering (ISIC), School of Basic Sciences (SB), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-2985-6932
Deep M PatelCenter for Catalytic Science and Technology and Delaware Energy Institute, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0003-1085-8927
Songlan SunLaboratory of Sustainable and Catalytic Processing (LPDC), Institute of Chemicals Sciences and Engineering (ISIC), School of Basic Sciences (SB), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0009-0004-1780-4766
Claire L BourmaudLaboratory of Sustainable and Catalytic Processing (LPDC), Institute of Chemicals Sciences and Engineering (ISIC), School of Basic Sciences (SB), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0009-0000-8594-1376
Tso-Hsuan ChenCenter for Catalytic Science and Technology and Delaware Energy Institute, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.
Dionisios G VlachosCenter for Catalytic Science and Technology and Delaware Energy Institute, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0002-6795-8403
Jeremy S LuterbacherLaboratory of Sustainable and Catalytic Processing (LPDC), Institute of Chemicals Sciences and Engineering (ISIC), School of Basic Sciences (SB), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-0967-0583

Funding

National Centre of Competence in ResearchNCCR Catalysis 180544Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung TMCG-2_213835
6 · The paper itself

Abstract

Xylose acetalization has emerged as a potent tool to extract this sugar from lignocellulosic biomass and for creating new biobased chemicals and materials. This article elucidates a generalized reaction network for xylose acetalization and reveals the role of aldehyde electrophilicity and ring strain in intermediate formation. Aldehydes with strong electrophilicity stabilize xylose as both furanose- and pyranose-monoacetals, whereas weaker aldehydes favour xylofuranose acetalization due to the high ring strain in pyranose acetals. The energetically favoured furanose diacetals dominate the product distribution over extended reaction time regardless of aldehyde types and reaction pathways. Measurements of the xylose tautomer ratio in the reaction conditions highlighted the importance of xylose isomerization in forming furanose acetals. These mechanistic insights not only explain the evolution of reaction intermediates but also aid in identifying potential products for sustainable chemical synthesis.

Indexed as

acetalizationcarbohydrateselectrophilicityreaction mechanismsring strainxylose

Identifiers

PMID41459828
PMCPMC12746704

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.