Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Simon J Y HanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0000-0001-8039-510X
Vinit AdaniSchool of Medicine Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA.
Edward FarrowDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0000-0003-4111-6408
Bhaval ParmarSchool of Medicine Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA.ORCID 0000-0001-7723-5439
Ching-Fang ChangDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0000-0001-6754-2769
Kim CochranDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0009-0001-4411-0653
Ronald R HorneSchool of Medicine Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA.
Paige J K RamkissoonDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.
Ezekiel EstebanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.
Kelsey H ElliottDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.
Brian GebeleinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0000-0001-9791-9061
Martín I García-CastroSchool of Medicine Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA.ORCID 0000-0001-5128-0004
Samantha A BrugmannDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 452294, USA.ORCID 0000-0002-6860-6450
Funding
Harnessing the therapeutic potential of neural crest cells by manipulating the primary ciliumR35DE027557 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2017 to 2024
$7.6M
Molecular Interactions During Neural Crest FormationR01DE017914 · NIDCR · YALE UNIVERSITY · PI GARCIA-CASTRO, MARTIN I. · 2007 to 2025
$6.3M
Predicting Tissue Specific Gli3 Regulatory Activity Using Hand2R01DE031750 · NIDCR · JACKSON LABORATORY · PI Samantha A Brugmann, Kevin Anthony Peterson · 2022 to 2026
$3.9M
Mechanisms of Homeodomain Transcription Factor SpecificityR35GM158075 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BRIAN GEBELEIN · 2025 to 2026
$1.0M
The role of Sonic hedgehog signaling in cranial neural crest potencyF31DE033565 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI HAN, SIMON JOON YOUNG · 2023 to 2024
Neural crest cells (NCCs) are a population of multipotent cells that undergo specification, epithelial-to-mesenchymal transition, migration and differentiation into a plethora of cell types. A wealth of studies across various embryonic model systems have established a dogma as to the molecular mechanisms and signaling cascades that contribute to NCC development. While Wnt, FGF and BMP signaling pathways have well-established and essential roles in several aspects of NCC development, the Hedgehog (HH) signaling pathway has received limited attention for any specific role in this process. Herein, we propose two distinct, temporal roles for the transcription factor GLI3 in NCC development. Gli3, and other members of the HH pathway, were robustly co-expressed with established NCC induction and specification markers in chick, mouse and human embryonic stem cell-derived NCCs. Early knockdown of GLI3 reduced expression of key markers of NCC specification and conditional knockout of Gli3 post-specification specifically impaired the ability of cranial NCCs to differentiate into ectomesenchymal derivatives. Together, these results demonstrate dual roles for GLI3 in early NCC specification and later in cranial NCC differentiation.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A dual role for GLI3 signaling in neural crest development. · full record | OpenQuestion