Evidence map›Paper›PMID 41459805›Full record

ArticleAnnals of neurology2026

Intranasal Seletracetam in a Patient with Reading Epilepsy: First-in-Human Use to Prevent Reflex Seizures.

Matthias J Koepp, Kai-Nicolas Poppert, Thomas Felder, Aljoscha Thomschewski, Sandra Lafenthaler, Pavel Klein, Alexander Rotenberg, Wolfgang Löscher, Chris Rundfeldt, Eugen Trinka

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthias J KoeppDepartment of Neurology, National Hospital for Neurology and Neurosurgery, Queens Square, London, UK.ORCID 0000-0002-4277-8000
Kai-Nicolas PoppertDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre of Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Member of EpiCARE, Salzburg, Austria.
Thomas FelderDepartment of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0001-8266-5513
Aljoscha ThomschewskiDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre of Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Member of EpiCARE, Salzburg, Austria.
Sandra LafenthalerDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre of Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Member of EpiCARE, Salzburg, Austria.
Pavel KleinMid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA.ORCID 0000-0001-7244-3722
Alexander RotenbergDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6495-5928
Wolfgang LöscherTranslational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany.
Chris RundfeldtDrug Consulting Network, Coswig, Germany.
Eugen TrinkaDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre of Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Member of EpiCARE, Salzburg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first human use of intranasal seletracetam (SEL) to prevent reflex seizures. A patient with epilepsy with reading-induced seizures on levetiracetam (3,000 mg/day) continued to experience reading-induced focal seizures with preserved consciousness. Detectable in serum within 2 minutes of intranasal administration, 30 mg seletracetam delayed seizure onset from 1:56 (placebo) to 4:17 minutes post-stimulus onset. A second 30 mg dose fully prevented seizures during 25 minutes of reading. Electroencephalogram (EEG) spike-frequency declined dose-dependently (3.1/min at placebo to 1.6/min after second dose), with reduced spike-propagation on magnetoencephalography (MEG). Our findings support SEL as a promising non-benzodiazepine acute seizure prevention and provide insight into reflex seizure dynamics. ANN NEUROL 2026;99:535-539.

Indexed as

AnticonvulsantsEpilepsy, ReflexSeizuresAdministration, IntranasalAdultElectroencephalographyFemaleHumansMagnetoencephalographyMaleReadingAnticonvulsants

Identifiers

PMID41459805
PMCPMC12894474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.