Evidence map›Paper›PMID 41459734›Full record

ArticleGut microbes2026

Xinhuang Lv, Tao Ye, Xiaolan Liao, Qiyao Li, Zheyu Fang, Xiaoou Lin, Mozi Chen, Conghui Dai, Lu Zhan, Linpei Zhuo and 3 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinhuang LvDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tao YeDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaolan LiaoDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qiyao LiDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zheyu FangDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaoou LinDepartment of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, China.
Mozi ChenDepartment of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, China.
Conghui DaiDepartment of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, China.
Lu ZhanDepartment of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, China.
Linpei ZhuoDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kun XiangDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jing SunDepartment of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiaming LiuDepartment of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-0483-3187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies have shown that commensal gut microbes may be involved in the pathogenesis of Alzheimer's disease (AD). The influence of gut microbe-derived metabolites, such as trimethylamine N-oxide (TMAO), has attracted a lot of attention. However, the influence and pathways mediated by gut microbe-derived metabolites in the pathogenesis of AD remain uncertain. Here, we observed a significant increase in the abundance of

Indexed as

Alzheimer DiseaseEubacterialesHypoxia-Inducible Factor 1, alpha SubunitMethylaminesAgedAnimalsDisease Models, AnimalDisease ProgressionFemaleGastrointestinal MicrobiomeHumansMaleMiceOxidative StressPhosphorylationSignal TransductionHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMethylaminestau ProteinstrimethyloxamineAlzheimer's diseaseBlautia coccoideshypoxia-inducible factor 1 alphaoxidative stresstrimethylamine N-oxide

Identifiers

PMID41459734
PMCPMC12758303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.