Evidence map›Paper›PMID 41459707›Full record

SynthesisClinical cardiology2026

Naples Prognostic Score and Clinical Outcomes After PCI for Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Yasin Özen, Mustafa Bilal Ozbay, Zahin Shahriar, Hüseyin Tezcan, Tugay Dedebali, Abdullah Tunçez, Muhammed Ulvi Yalçin, Kadri Murat Gürses, Bülent Özbay

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yasin ÖzenDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0002-5379-249X
Mustafa Bilal OzbayDepartment of Medicine, Penn Medicine Princeton Medical Center, Plainsboro, New Jersey, USA.ORCID https://orcid.org/0000-0003-2760-1028
Zahin ShahriarDepartment of Cardiology, Dhaka Medical College Hospital, Dhaka, Bangladesh.ORCID https://orcid.org/0009-0003-9480-7402
Hüseyin TezcanDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0002-8140-874X
Tugay DedebaliDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.
Abdullah TunçezDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0002-6512-1327
Muhammed Ulvi YalçinDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0003-3750-8011
Kadri Murat GürsesDepartment of Cardiology, Konya Selcuk University Medical Faculty Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0003-3904-0985
Bülent ÖzbayDepartment of Pulmonary Medicine, Faculty of Medicine, Muğla Sıtkı Kocman University, Muğla, Turkey.ORCID https://orcid.org/0009-0000-9600-8530

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNaples Prognostic Score (NPS), a composite index incorporating inflammatory and nutritional markers, has emerged as a potential prognostic tool in various cardiovascular conditions; however, no meta-analysis has yet pooled the available evidence to comprehensively assess its prognostic utility.

objectivesTo evaluate the association of NPS with clinical outcomes, including all-cause mortality, in-hospital mortality, no-reflow (NR) phenomenon, and left ventricular ejection fraction (LVEF), in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).

methodsMEDLINE, Cochrane, and EMBASE databases were searched for studies comparing high and low NPS groups in ACS patients undergoing PCI. Random-effects models were used to pool risk ratios (RR) for binary outcomes and mean differences (MD) for continuous outcomes. Heterogeneity was assessed with I² statistics. Statistical analyses were performed using Review Manager 5.4, and R, version 4.2.2.

resultsWe included seven studies comprising 13 268 patients, with 5628 (42.4%) patients in the low NPS group. Low NPS was significantly associated with decreased all-cause mortality (RR: 0.42; 95% CI: 0.32-0.55; I² = 48%) and decreased incidence of NR (RR: 0.60; 95% CI: 0.40-0.88; I² = 83%). Patients with low NPS also had higher LVEF (MD: -2.69%; 95% CI: -3.41 to -1.97; I² = 99%). No significant difference was observed in in-hospital mortality (RR: 0.54; 95% CI: 0.28-1.05; I² = 94%).

conclusionIn ACS patients undergoing PCI, elevated NPS was associated with worse clinical outcomes. These findings support the use of NPS as a practical, biomarker-based tool for risk stratification in this population.

Indexed as

Acute Coronary SyndromeNutritional StatusPercutaneous Coronary InterventionBiomarkersGlobal HealthHospital MortalityHumansPrognosisRisk AssessmentRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftBiomarkers

Identifiers

PMID41459707
PMCPMC12746426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.