ArticleComputational and structural biotechnology journal2025
Model-based evaluation of connexin hemichannel permeability.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Connexin (Cx) hemichannels form intercellular gap junction channels but can also function independently. These large-pore channels are permeable not only to ions but also to small signalling molecules and metabolites. This functional property is relevant to many physiological processes and can be altered by various biochemical factors or disease-causing mutations. In this study, we present a methodology for quantifying and comparing the permeabilities of hemichannels formed by different Cx isoforms using a combination of fluorescence imaging, electrophysiological recordings and mathematical modelling. Fluorescence imaging, coupled with mathematical modelling based on Fick's law and/or the Goldman-Hodgkin-Katz current equation, enables assessment of tracer diffusion rates. These data are integrated with independently obtained electrophysiological measurements of hemichannel activity into a unified statistical model based on the likelihood ratio test. Simulation-based analyses demonstrate that this approach can reliably detect differences as low as two-fold in hemichannel permeability using datasets of moderate size (
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