ArticleFrontiers in immunology2025
Evaluation of programmed cell death ligand-1 expression in primary central nervous system lymphoma using whole-tumor histogram analysis of multiparametric MRI: implications for immunotherapy selection.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To assess the diagnostic performance of whole-tumor histogram analysis of multiparametric MRI in predicting programmed cell death ligand-1 (PD-L1) expression in primary central nervous system lymphoma (PCNSL). Methods: A total of 130 patients with PCNSL (61 males, aged 21-80 years) were included in the study. Histogram features derived from T2-weighted imaging (T2WI), T1-weighted imaging (T1WI), fluid-attenuated inversion recovery (FLAIR), contrast-enhanced T1-weighted imaging (T1WI+C), and apparent diffusion coefficient (ADC) were compared between the low and high PD-L1 expression groups using the Mann-Whitney U test. Receiver operating characteristic (ROC) curves and logistic regression analysis were applied to assess the diagnostic performance of both individual and combined models in predicting PD-L1 expression levels in PCNSL. Results: Eighteen histogram features extracted from multiparametric MRI exhibited significant differences between high and low PD-L1 expression in PCNSL (all Conclusions: Whole-tumor histogram analysis of multiparametric MRI shows potential as a non-invasive method for evaluating PD-L1 expression in PCNSL, which may assist in the identification of immunotherapy-eligible patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.