Evidence map›Paper›PMID 41459533›Full record

ArticleFrontiers in immunology2025

MMP-9 affects dural cell composition and granulocyte accumulation during neuroinflammation.

Sheng-Hsiang Shen, Hanna Gerwien, Miriam Burmeister, Yi-Ling Tsang, I-Na Lu, Anna-Lena Börsch, Tushar Deshpande, Lydia Sorokin, Gerd Meyer Zu Hörste

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheng-Hsiang Shen *Department of Neurology, Medical Faculty, University Hospital Muenster, Münster, Germany.
Hanna Gerwien *Institute of Physiological Chemistry and Pathobiochemistry, and Cells-in-Motion Interfaculty Centre (CiMIC), University of Muenster, Münster, Germany.
Miriam Burmeister *Institute of Physiological Chemistry and Pathobiochemistry, and Cells-in-Motion Interfaculty Centre (CiMIC), University of Muenster, Münster, Germany.
Yi-Ling TsangInstitute of Physiological Chemistry and Pathobiochemistry, and Cells-in-Motion Interfaculty Centre (CiMIC), University of Muenster, Münster, Germany.
I-Na LuDepartment of Pediatric Hematology and Oncology, University Hospital Muenster, Münster, Germany.
Anna-Lena BörschDepartment of Neurology, Medical Faculty, University Hospital Muenster, Münster, Germany.
Tushar DeshpandeInstitute of Physiological Chemistry and Pathobiochemistry, and Cells-in-Motion Interfaculty Centre (CiMIC), University of Muenster, Münster, Germany.
Lydia Sorokin *Institute of Physiological Chemistry and Pathobiochemistry, and Cells-in-Motion Interfaculty Centre (CiMIC), University of Muenster, Münster, Germany.
Gerd Meyer Zu Hörste *Department of Neurology, Medical Faculty, University Hospital Muenster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Matrix metalloproteinases MMP-2 and MMP-9 modulate inflammatory processes at the blood-brain barrier (BBB), but their presence and function in the dura mater remain unclear. We therefore investigated their contribution to immune regulation at this site during neuroinflammation. Methods: We analyzed dura mater from naïve and experimental autoimmune encephalomyelitis (EAE) mice using immunofluorescence, gelatin zymography, flow cytometry, and single-nucleus RNA sequencing (snRNA-seq). Comparisons were performed between wild-type (WT) and Results: Pro- and activated-MMP-2 and MMP-9 were detectable in naïve dura, with selective upregulation of MMP-9 during EAE. Discussion: Our findings indicate that MMP-9 regulates immune cell composition and activation within the dura during neuroinflammation. While

Indexed as

Dura MaterEncephalomyelitis, Autoimmune, ExperimentalGranulocytesMatrix Metalloproteinase 9Neuroinflammatory DiseasesAnimalsBlood-Brain BarrierFemaleMatrix Metalloproteinase 2MiceMice, Inbred C57BLMice, KnockoutMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp9 protein, mousedura materexperimental autoimmune encephalomyelitis (EAE)matrix metalloproteinase-9 (MMP-9)meningeal immunityneuroinflammationneutrophil granulocytessingle-nucleus RNA sequencing (snRNA-seq)

Identifiers

PMID41459533
PMCPMC12738929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.