Evidence map›Paper›PMID 41459526›Full record

ArticleFrontiers in immunology2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR.

Wang Luoying, Yi Xingcheng, Cong Donghang, Long Mengtuan, Wang Ping, Zhang Lijuan, Li Yupeng, Zhao Tianyi, Chen Hongyu, Wang Song and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wang Luoying *Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Yi Xingcheng *Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China.
Cong DonghangDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Long MengtuanLaboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China.
Wang PingDepartment of Otolaryngology-Head and Neck Surgery, First Hospital of Jilin University, Changchun, China.
Zhang LijuanDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Li YupengLaboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China.
Zhao TianyiInstitute of Changbai Mountain Biology Germplasm Resources, Tonghua Normal University, Tonghua Jilin, China.
Chen HongyuSchool of Software, Tsinghua University, Beijing, China.
Wang SongDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Zang ZijunDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Zheng HanyuDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Chen ShengchaoDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Fu CongKey Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
Su XiaoyunDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major global health burden, with current therapies limited by metabolic adaptation and adverse effects. Although transcriptomic studies reveal widespread gene alterations in obesity, key drivers and their cell-specific origins in adipose tissue remain unclear. Defining these regulators is critical for understanding immune-metabolic imbalance and developing targeted interventions. We integrated bulk transcriptomics (n=434) with single-cell RNA-seq (194,608 cells from 24 adipose samples) to identify BMI-associated gene modules and macrophage regulatory programs. Cell-specific networks, subtype-specific gene regulatory networks, pseudotime trajectories, and cell-cell communication analyses delineated macrophage heterogeneity. Molecular docking assessed interactions between candidate drugs and the TREM2-DAP12-SYK pathway, and

Indexed as

Adaptor Proteins, Signal TransducingAdipose TissueCatechinMacrophage ActivationMacrophagesMembrane GlycoproteinsMembrane ProteinsObesityReceptors, ImmunologicSyk KinaseAnimalsDiet, High-FatFemaleHumansMaleMiceAdaptor Proteins, Signal TransducingCatechinepigallocatechin gallateMembrane GlycoproteinsMembrane ProteinsReceptors, ImmunologicSyk KinaseSyk protein, mouseTREM2 protein, humanTrem2 protein, mouseadipose tissue microenvironmentmacrophagesobesitysingle-cell gene regulatory networkstargeted drugscreening

Identifiers

PMID41459526
PMCPMC12739555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.